A study on regulation of synaptic dopamine concentration by antipsychotic agent

• Project/Area Number: 24791249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Jikei University School of Medicine (2014); National Institute of Radiological Sciences (2012-2013)
• Principal Investigator: KODAKA FUMITOSHI 東京慈恵会医科大学, 医学部, 助教 (10349582)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ドーパミン / ドーパミントランスポーター / 抗精神病薬 / リスペリドン / ドーパミン再取り込み能 / ドーパミン生成能

Outline of Final Research Achievements

We investigated effects of antipsychotic agent risperidone on synaptic dopamine transporter (DAT) density with positron emission tomography (PET) in healthy male subjects. We calculated DAT binding potential (BP) which reflects DAT density after administration of risperidone and placebo. Although we have no statistical differences between DAT BP values after administration of risperidone and placebo, we found significant correlation between rate of change in DAT BP by risperidone and blood concentration of risperidone.