| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The function of Selective Serotonin Reuptake Inhibitors (SSRI) is suggested to relate to the serotonin level in the brain. In this study, we evaluated a method to measure the serotonin level noninvasively from the outside of the body using PET. First, computer simulation was performed to establish the analysis method to detect the changes in the serotonin level from PET images. As a result, the binding potential of receptors estimated by a compartment model with a reference region was demonstrated to correlate with an amount of increase in the serotonin concentration. Next, this method was applied to PET measurements of serotonin receptors for small animals. The binding potentials obtained from PET images became lower after the increase of serotonin concentration caused by administration of SSRI, suggesting the proposed method would be useful for the measurement of changes in serotonin level in the human brain.
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