Neural mechanism of resistance to sympathy

• Project/Area Number: 24791251
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: YAMADA Makiko 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, サブリーダー (50557444)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 共感 / 認知神経科学 / 認知科学 / 神経科学 / 脳・神経 / 社会性 / 社会神経科学

Outline of Final Research Achievements

Perception of someone in pain does not always induce sympathy in perceivers. In particular, resistance to sympathy has been considered as a serious problem in clinical settings. The present study aimed to uncover the neural mechanism of resistance to sympathy, and found the desire to feel superior to others, which was a component of sympathy, was generated by the interrelationship between the dopamine neurotransmission in striatum and the stratal functional connectivity. Moreover, dopamine neurotransmissions in striatum and orbitofrontal cortex were associated with the perspective taking ability and Machavellianism, respectively, both of which were related to resistance to sympathy.

Research Products

• [Journal Article] Superiority illusion arises from resting-state brain network modulated by dopamine. (2013)
  • Author(s): Yamada, M., Uddin, L. Q., Takahashi, H., Kimura, Y., Takahata, K., Kousa, R., Ikoma, Y., Eguchi, Y., Takano, H., Ito, H., Higuchi, M., & Suhara, T.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Issue: 11 Pages: 4363-4367
  • DOI: 10.1073/pnas.1221681110
  • Peer Reviewed
• [Journal Article] Effect of cooperation level of group on punishment for non-cooperators: a functional magnetic resonance imaging study. (2012)
  • Author(s): Fumitaka Kodaka
  • Journal Title: PLoS One. Volume: 7 Issue: 7 Pages: e41338-e41338
  • DOI: 10.1371/journal.pone.0041338
  • Peer Reviewed
• [Journal Article] 視床と主観的体験 (2012)
  • Author(s): 山田 真希子
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 90-92
• [Presentation] ヒト共感性の分子・神経基盤 (2014)
  • Author(s): 山田 真希子
  • Organizer: 2014年度包括脳ネットワーク 冬のシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-12-13
  • Invited
• [Presentation] Dopamine D2 Receptors in the Orbitofrontal Cortex and the Machiavellianism. (2014)
  • Author(s): Moriguchi S, Suhara T, Yamada M
  • Organizer: The 10th International symposium on Functional NeuroReceptor Mapping of the Living Brain
  • Place of Presentation: The Netherland
  • Year and Date: 2014-05-11
• [Presentation] Dopamine D2 Receptors in the Orbitofrontal Cortex and the Machiavellianism (2014)
  • Author(s): Sho Moriguchi, Tetsuya Suhara, Makiko Yamada
  • Organizer: NRM
  • Place of Presentation: オランダ
• [Presentation] A wide distribution of empathy in resting-state pain network (2013)
  • Author(s): 山田 真希子、高野 晴成、横川 啓太、小宇佐 梨里子、須原 哲也
  • Organizer: 脳と心のメカニズム 第13回冬のワークショップ
  • Place of Presentation: 北海道
• [Presentation] Chihiro Sutou、Daisuke Matsuzawa、Yoshiyuki Hirano、Makiko Yamada、Hiroshi Ito、Hiroshi Tsuji、Takayuki Obata、Eiji Shimizu,et.al (2013)
  • Author(s): 須藤 千尋、松澤 大輔、平野 好幸、山田 真希子、伊藤 浩、辻 比呂志、小畠 隆行、清水 栄司、その他
  • Organizer: 第5回日本不安障害学会学術大会
  • Place of Presentation: 北海道
• [Presentation] Facial emotion recognition of anger after anteromedial temporal lobectomy in patients with epilepsy (2012)
  • Author(s): Satsuki Watanabe、Makiko Yamada, et.al
  • Organizer: American Epilepsy Society annual meeting 2012
  • Place of Presentation: アメリカ
• [Presentation] 情状酌量の脳機能メカニズム (2012)
  • Author(s): 山田 真希子
  • Organizer: 日本心理学会
  • Place of Presentation: 神奈川
  • Invited