| Project/Area Number |
24791253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NAKAHACHI Takayuki 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 児童・思春期精神保健研究部, 研究生 (40615530)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 実行機能 / 神経発達障害 / 大脳小脳連関 / 前頭葉 / 光トポグラフィー / 脳磁図 / 自閉症スペクトラム障害 / 限局的反復的行動 / 反復的限局的行動 / 小脳大脳連関 / diaschisis |
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| Outline of Final Research Achievements |
This study aims to explore neural substrates of restricted repetitive behaviors (RRBs), which is a critical behavioral characteristic of autism spectrum disorders. Study 1: Executive dysfunction which is a cognitive substrate of RRBs was focused on, and development of the task to investigate it under neuroimaging techniques even in children was attempted. Near-infrared spectroscopy (NIRS) using the word generation task was conducted to 25 healthy volunteers. Bilateral prefrontal and superior temporal cortex were activated. Study 2: Purposing to detect deficits of cerebral-cerebellum linkage, which is considered to a candidate of RRBs' biomarker, utility of NIRS and magnetoencephalography available to children was investigated using the hand grasping task in a patient of neurodevelopmental disorder with cerebellar lesions, and crossed cerebellocerebral diaschisis was clarified.
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