Exploration of biomarkers ralated to restricted repetitive behaviors in autistic children
| Project/Area Number |
24791253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NAKAHACHI Takayuki 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 児童・思春期精神保健研究部, 研究生 (40615530)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 実行機能 / 神経発達障害 / 大脳小脳連関 / 前頭葉 / 光トポグラフィー / 脳磁図 / 自閉症スペクトラム障害 / 限局的反復的行動 / 反復的限局的行動 / 小脳大脳連関 / diaschisis |
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| Outline of Final Research Achievements |
This study aims to explore neural substrates of restricted repetitive behaviors (RRBs), which is a critical behavioral characteristic of autism spectrum disorders. Study 1: Executive dysfunction which is a cognitive substrate of RRBs was focused on, and development of the task to investigate it under neuroimaging techniques even in children was attempted. Near-infrared spectroscopy (NIRS) using the word generation task was conducted to 25 healthy volunteers. Bilateral prefrontal and superior temporal cortex were activated. Study 2: Purposing to detect deficits of cerebral-cerebellum linkage, which is considered to a candidate of RRBs' biomarker, utility of NIRS and magnetoencephalography available to children was investigated using the hand grasping task in a patient of neurodevelopmental disorder with cerebellar lesions, and crossed cerebellocerebral diaschisis was clarified.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Frontal midline theta rhythm and gamma power changes during focused attention on mental calculation: an MEG beamformer analysis.2014
Author(s)
Ishii R, Canuet L, Ishihara T, Aoki Y, Ikeda S, Hata M, Katsimichas T, Gunji A, Takahashi H, Nakahachi T, Iwase M, Takeda M.
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Journal Title
Front Hum Neurosci.
Volume: 8
Pages: 406-406
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Acoustic startle modulation and its relationship to quantitative autistic traits in Japanese children with and without autism spectrum disorders2013
Author(s)
H. TAKAHASHI, T. NAKAHACHI, A. MORIWAKI, Y. IIDA, A. ENDO, K. OGINO, R. TAKEI, S. KOMATSU, Y. KAMIO
Organizer
Neuroscience 2013
Place of Presentation
San Diego Convention Center, California, San Diego, USA
Related Report
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