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Long-term use of hypnotics in Japan

Research Project

Project/Area Number 24791256
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNeuropsychiatric Research Institute

Principal Investigator

ENOMOTO Minori  公益財団法人神経研究所, 研究部, 研究員 (60415578)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords睡眠薬 / 常用量依存 / 診療報酬情報 / 精神生理学 / 睡眠障害 / 睡眠
Research Abstract

This study aimed at revealing the current status of long-term hypnotics use and the risk factor accounting for long-term use among Japanese, with the use of large-sized health insurance data. Data were derived from medical fee receipts of approximately 330,000 people enrolled in multiple health insurance associations in Japan. We selected adult patients who were prescribed at least one hypnotic for the first time between April 2005 and March 2008. Follow-up was extended to March 2009. To reveal the risk factor of long-term use of hypnotics, we performed Cox regression analyses with time-dependent variables in those patients who were followed up for up to 12 months. A total of 3,981 patients (M:2,382 F:1,579, 40.3plus or minus12.4) were prescribed hypnotics first time during the study period. The present findings indicate that insomnia comorbid with depression patients were likely to continue to be prescribed hypnotics for a longer period of time.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (10 results)

  • [Journal Article] In vitro circadian period is associated with circadian/sleep preference.2013

    • Author(s)
      Hida A, 他16名
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2074-2074

    • DOI

      10.1038/srep02074

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep debt elicits negative emotional reaction through diminished amygdala-anterior cingulate functional connectivity2013

    • Author(s)
      Motomura Y., ほか9名
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: 1-10

    • DOI

      10.1371/journal.pone.0056578

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type2013

    • Author(s)
      Kitamura S, Hida A, Enomoto M, et al
    • Journal Title

      Biol Psychiatry

      Volume: vol.73 Pages: 63-69

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activity in the action observation network enhances emotion regulation during observation of risk-taking: an fMRI study.2013

    • Author(s)
      Tamura M, Moriguchi Y, Higuchi S, Hida A, Enomoto M, Umezawa J, Mishima K.
    • Journal Title

      Neurol Res.

      Volume: 35(1) Issue: 1 Pages: 22-8

    • DOI

      10.1179/1743132812y.0000000109

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic Circadian Period of Sighted Patients with Circadian Rhythm Sleep Disorder, Free-Running Type2013

    • Author(s)
      Kitamura S.
    • Journal Title

      Biol Psychiatry

      Volume: 73(1) Issue: 1 Pages: 63-9

    • DOI

      10.1016/j.biopsych.2012.06.027

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者のPSG 記録と判定のピットフォール2012

    • Author(s)
      榎本みのり, 三島和夫
    • Journal Title

      睡眠医療

      Volume: vol.6 Pages: 325-311

    • Related Report
      2013 Final Research Report
  • [Journal Article] 睡眠検査のピットフォール -実施上の注意点・問題点- 第5回 高齢者のPSG記録と判定のピットフォール2012

    • Author(s)
      榎本みのり、三島和夫
    • Journal Title

      睡眠医療

      Volume: 6 Pages: 325-331

    • NAID

      40019368740

    • Related Report
      2012 Research-status Report
  • [Presentation] 不眠症とうつ病の合併患者の受療行動2013

    • Author(s)
      榎本みのり, 草薙宏明, 北村真吾, 三島和夫
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田県県民会館(秋田県 秋田市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 不眠症とうつ病の合併患者の受療行動2013

    • Author(s)
      榎本みのり, 草薙宏明, 北村真吾, 三島和夫
    • Organizer
      第10回日本うつ病学会総会
    • Place of Presentation
      北九州国際会議場(福岡県 北九州市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 不眠症とうつ病の合併患者の受療行動2013

    • Author(s)
      榎本みのり、草薙宏明、北村真吾、三島和夫
    • Organizer
      日本睡眠学会第38 回定期学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 不眠症とうつ病の合併患者の受療行動2013

    • Author(s)
      榎本みのり、草薙宏明、北村真吾、三島和夫
    • Organizer
      第10回日本うつ病学会総会
    • Place of Presentation
      北九州
    • Related Report
      2013 Annual Research Report
  • [Presentation] 不眠症状と抑うつリスク -レセプトデータ解析から-2012

    • Author(s)
      榎本みのり, 北村真吾, 野崎健太郎, 片寄泰子, 肥田昌子, 三島和夫
    • Organizer
      第37回日本睡眠学会定期学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 不眠症患者の受療行動からの抑うつリスクの検討2012

    • Author(s)
      榎本みのり, 北村真吾, 草薙宏明, 三島和夫
    • Organizer
      第42回日本精神神経薬理学会
    • Place of Presentation
      栃木県総合文化センター(栃木県 宇都宮市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Patterns of hypnotics and antidepressants prescription in Japan2012

    • Author(s)
      Enomoto M, Kitamura S, Kusanagi H, and Mishima K
    • Organizer
      The 7th Asian Sleep Research Society Congress
    • Place of Presentation
      Taipei International Convention Center (Taipei, Taiwan)
    • Related Report
      2013 Final Research Report
  • [Presentation] 不眠症状と抑うつリスク ―レセプトデータ解析から―2012

    • Author(s)
      榎本みのり,北村真吾,野崎健太郎,片寄泰子,肥田昌子,三島和夫
    • Organizer
      第37回日本睡眠学会定期学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 不眠症患者の受療行動からの抑うつリスクの検討2012

    • Author(s)
      榎本みのり, 北村真吾, 草薙宏明, 三島和夫
    • Organizer
      第42回日本精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Research-status Report
  • [Presentation] Patterns of hypnotics and antidepressants prescription in Japan2012

    • Author(s)
      Minori Enomoto, Shingo Kitamura, Hiroaki Kusanagi, and Kazuo Mishima
    • Organizer
      The 7th Asian Sleep Research Society Congress
    • Place of Presentation
      台北、台湾
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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