Development of a new method for gated radiotherapy using multiple gating points with a real time tumor tracking system.

• Project/Area Number: 24791260
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: KATOH Norio 北海道大学, 大学病院, 助教 (80572495)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線治療 / 放射線 / 動体追跡 / 臓器移動 / 呼吸同期CT

Outline of Final Research Achievements

The efficacy of four-dimensional computed tomography (4DCT) before stereotactic body radiotherapy (SBRT) for peripheral lung tumors was evaluated. The amplitude of a fiducial marker implanted near a lung tumor was measured using the maximum intensity projection (MIP) method in 4DCT imaging acquired before SBRT and compared with that measured during SBRT using real-time tumor-tracking radiotherapy (RTRT) system. In the lower lobe, the mean discrepancy from the amplitude measured with 4DCT to the mean of maximum amplitude of the patient during SBRT was 5.7 ± 8.0 mm, 12.5 ± 16.7 mm, 6.8 ± 8.5 mm in the LR, CC, and AP direction, respectively. 4DCT MIP before SBRT underestimates the maximum amplitude during actual SBRT. Caution must be paid to determine the margin with 4DCT especially for tumors in the lower lobe. More research is needed to establish a new method for gated radiotherapy using multiple gating points.

Research Products

• [Presentation] 照射中と4DCT撮像時の肺内マーカー移動の比較 (2014)
  • Author(s): 原田慶一、加藤徳雄、鈴木隆介、井上哲也、鬼丸力也、清水伸一、宮本直樹、石川正純、白土博樹
  • Organizer: 第131回日本医学放射線学会北日本地方会
  • Place of Presentation: 東北大学艮陵会館（仙台市）
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Japanese Multi-institutional Study of Stereotactic Body Radiation Therapy For Renal and Adrenal Tumors (2014)
  • Author(s): Katoh N, Onishi H, Matsushita H, Nomiya K, Nakata K, Shirato H
  • Organizer: American Society for Radiation Oncology 56th Annual Meeting
  • Place of Presentation: Moscone Center (San Francisco, USA)
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] The Planning Simulation of Dose-Painting Radiotherapy using 18F-MISO PET for Lung Cancer (2014)
  • Author(s): Nishikawa Y, Yasuda K, Inoue T, Katoh N, Tsuchiya K, Okamoto S, Oizumi S, Harada K, Onimaru R, Shiga T, Watanabe S, Kuge Y, Sakakibara-Konishi J, Shinagawa N, Tamaki N, Shirato H
  • Organizer: The 12th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: The Alumni Hall "Frate" (Sapporo, Japan)
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] Can 4DCT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy? (2013)
  • Author(s): K. Harada, N. Katoh, R. Suzuki, T. Inoue, R. Onimaru, S.Shimizu, N. Miyamoto, M. Ishikawa, H. Shirato
  • Organizer: American Society for Radiation Oncology 55th Annual Meeting
  • Place of Presentation: Georgia World Congress Center (Atlanta, USA)
• [Presentation] A Retrospective Multicenter Study of Stereotactic Body Radiation Therapy Using a Real-Time Tumor-Tracking Radiation Therapy System for Stage I Non-Small Cell Lung Cancer (2013)
  • Author(s): N. Katoh, I. Soda, H. Tamamura, S. Takahashi, T. Inoue, R. Onimaru, K. Shibuya, K. Hayakawa, H. Shirato
  • Organizer: American Society for Radiation Oncology 55th Annual Meeting
  • Place of Presentation: Georgia World Congress Center (Atlanta, USA)
• [Presentation] 4DCTを用いた肺内マーカー移動の解析 (2013)
  • Author(s): 加藤 徳雄、原田 慶一、鈴木 隆介、井上 哲也、鬼丸 力也、清水 伸一、宮本 直樹、白土 博樹
  • Organizer: 第128回日本医学放射線学会北日本地方会
  • Place of Presentation: 朱鷺メッセ (新潟)
• [Presentation] 照射中と4DCT撮像時の肺内マーカー移動の比較 (2013)
  • Author(s): 原田慶一、加藤徳雄、鈴木隆介、井上哲也、鬼丸力也、清水伸一、宮本直樹、石川正純、白土博樹
  • Organizer: 第26回日本高精度放射線外部照射研究会
  • Place of Presentation: 京都テルサ（京都）
• [Presentation] FEASIBILITY OF TREATMENT OF GASTRIC LYMPHOMA WITH GATED RADIATION THERAPY USING A REAL-TIME TUMOR-TRACKING SYSTEM (2012)
  • Author(s): Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
  • Organizer: 31st Sapporo International Cancer Symposium
  • Place of Presentation: Hokkaido University The Alumni Hall "Frate" (Sapporo)
• [Presentation] Real-time tumor tracking radiation therapy for lymphoma of the stomach. (2012)
  • Author(s): Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center (Boston, USA)
• [Patent(Industrial Property Rights)] 放射線治療システムおよび放射線治療プログラム (2015)
  • Inventor(s): 宮本直樹、加藤徳雄 他5名
  • Industrial Property Rights Holder: 宮本直樹、加藤徳雄 他5名
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-01-20