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Development of a new method for gated radiotherapy using multiple gating points with a real time tumor tracking system.

Research Project

Project/Area Number 24791260
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

KATOH Norio  北海道大学, 大学病院, 助教 (80572495)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線治療 / 放射線 / 動体追跡 / 臓器移動 / 呼吸同期CT
Outline of Final Research Achievements

The efficacy of four-dimensional computed tomography (4DCT) before stereotactic body radiotherapy (SBRT) for peripheral lung tumors was evaluated. The amplitude of a fiducial marker implanted near a lung tumor was measured using the maximum intensity projection (MIP) method in 4DCT imaging acquired before SBRT and compared with that measured during SBRT using real-time tumor-tracking radiotherapy (RTRT) system. In the lower lobe, the mean discrepancy from the amplitude measured with 4DCT to the mean of maximum amplitude of the patient during SBRT was 5.7 ± 8.0 mm, 12.5 ± 16.7 mm, 6.8 ± 8.5 mm in the LR, CC, and AP direction, respectively. 4DCT MIP before SBRT underestimates the maximum amplitude during actual SBRT. Caution must be paid to determine the margin with 4DCT especially for tumors in the lower lobe. More research is needed to establish a new method for gated radiotherapy using multiple gating points.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012

All Presentation (9 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 照射中と4DCT撮像時の肺内マーカー移動の比較2014

    • Author(s)
      原田慶一、加藤徳雄、鈴木隆介、井上哲也、鬼丸力也、清水伸一、宮本直樹、石川正純、白土博樹
    • Organizer
      第131回日本医学放射線学会北日本地方会
    • Place of Presentation
      東北大学艮陵会館(仙台市)
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Japanese Multi-institutional Study of Stereotactic Body Radiation Therapy For Renal and Adrenal Tumors2014

    • Author(s)
      Katoh N, Onishi H, Matsushita H, Nomiya K, Nakata K, Shirato H
    • Organizer
      American Society for Radiation Oncology 56th Annual Meeting
    • Place of Presentation
      Moscone Center (San Francisco, USA)
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Planning Simulation of Dose-Painting Radiotherapy using 18F-MISO PET for Lung Cancer2014

    • Author(s)
      Nishikawa Y, Yasuda K, Inoue T, Katoh N, Tsuchiya K, Okamoto S, Oizumi S, Harada K, Onimaru R, Shiga T, Watanabe S, Kuge Y, Sakakibara-Konishi J, Shinagawa N, Tamaki N, Shirato H
    • Organizer
      The 12th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      The Alumni Hall "Frate" (Sapporo, Japan)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Can 4DCT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?2013

    • Author(s)
      K. Harada, N. Katoh, R. Suzuki, T. Inoue, R. Onimaru, S.Shimizu, N. Miyamoto, M. Ishikawa, H. Shirato
    • Organizer
      American Society for Radiation Oncology 55th Annual Meeting
    • Place of Presentation
      Georgia World Congress Center (Atlanta, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] A Retrospective Multicenter Study of Stereotactic Body Radiation Therapy Using a Real-Time Tumor-Tracking Radiation Therapy System for Stage I Non-Small Cell Lung Cancer2013

    • Author(s)
      N. Katoh, I. Soda, H. Tamamura, S. Takahashi, T. Inoue, R. Onimaru, K. Shibuya, K. Hayakawa, H. Shirato
    • Organizer
      American Society for Radiation Oncology 55th Annual Meeting
    • Place of Presentation
      Georgia World Congress Center (Atlanta, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 4DCTを用いた肺内マーカー移動の解析2013

    • Author(s)
      加藤 徳雄、原田 慶一、鈴木 隆介、井上 哲也、鬼丸 力也、清水 伸一、宮本 直樹、白土 博樹
    • Organizer
      第128回日本医学放射線学会北日本地方会
    • Place of Presentation
      朱鷺メッセ (新潟)
    • Related Report
      2013 Research-status Report
  • [Presentation] 照射中と4DCT撮像時の肺内マーカー移動の比較2013

    • Author(s)
      原田慶一、加藤徳雄、鈴木隆介、井上哲也、鬼丸力也、清水伸一、宮本直樹、石川正純、白土博樹
    • Organizer
      第26回日本高精度放射線外部照射研究会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] FEASIBILITY OF TREATMENT OF GASTRIC LYMPHOMA WITH GATED RADIATION THERAPY USING A REAL-TIME TUMOR-TRACKING SYSTEM2012

    • Author(s)
      Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
    • Organizer
      31st Sapporo International Cancer Symposium
    • Place of Presentation
      Hokkaido University The Alumni Hall "Frate" (Sapporo)
    • Related Report
      2012 Research-status Report
  • [Presentation] Real-time tumor tracking radiation therapy for lymphoma of the stomach.2012

    • Author(s)
      Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center (Boston, USA)
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 放射線治療システムおよび放射線治療プログラム2015

    • Inventor(s)
      宮本直樹、加藤徳雄 他5名
    • Industrial Property Rights Holder
      宮本直樹、加藤徳雄 他5名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-20
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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