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Development of the real-time four-dimensional cone beam CT reconstruction technique for interactive radiotherapy

Research Project

Project/Area Number 24791261
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

TAKAO Seishin  北海道大学, 医学(系)研究科(研究院), 助教 (10614216)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線治療 / コーンビームCT / 四次元再構成 / CBCT
Research Abstract

We have proposed a novel method for four-dimensional (4D) cone-beam computed tomography (CBCT) reconstruction with real-time tumor tracking technique. In the real-time tumor tracking, a fiducial marker inserted near the tumor is detected in the orthogonal fluoroscopic images. The three-dimensional position of the marker is calculated every 33 msec with an accuracy of 1 mm. According to the position of the marker, projection images can be classified into some phases. Four dimensional CBCT reconstruction is therefore available in each phase. Feasibility of the 4D CBCT reconstruction was evaluated through the experience using the testing machine, which has the same imaging devices in the proton therapy system in Hokkaido University Hospital. Additionally, characteristics of intrafractional baseline shift of tumor motion were analyzed to investigate efficacy of the 4D CBCT reconstruction method. Through the study, the feasibility and efficacy of the 4D CBCT reconstruction was confirmed.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy : an initial phantom study using patient tumor trajectory data2013

    • Author(s)
      Matsuura T, Miyamoto N, Shimizu S, Fujii Y, Umezawa M, Takao S, Nihongi H, Toramatsu C, Sutherland K, Suzuki R, Ishikawa M, Kinoshita R, Maeda K, Umegaki K, and Shirato H
    • Journal Title

      Med Phys

      Volume: 40(7) Pages: 71729-71729

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning2012

    • Author(s)
      Mizuta M, Date H, Takao S, Kishimoto N, Sutherland KL, Onimaru R, and Shirato H
    • Journal Title

      Med Phys

      Volume: 39(11) Pages: 6791-6795

    • NAID

      120005108216

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Development and Commissioning of the Spot Scanning Proton Beam Therapy System2014

    • Author(s)
      Takao S, Toramatsu C, Matsuura T, Nihongi H, Yamada T, Miyamoto N, Shimizu S, Hashimoto T, Onimaru R, Kinoshita R, Onodera S, Umegaki K, and Shirato H
    • Organizer
      1st GI-CoRE Medical Science and Engineering Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2014-02-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Development and Commissioning of the Spot Scanning Proton Beam Therapy System2014

    • Author(s)
      Takao S, Toramatsu C, Matsuura T, Nihongi H, Yamada T, Miyamoto N, Shimizu S, Hashimoto T, Onimaru R, Kinoshita R, Onodera S, Umegaki K, and Shirato H
    • Organizer
      1st GI-CoRE Medical Science and Engineering Symposium
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 陽子線治療における高精度位置決め用コーンビームCT の開発2013

    • Author(s)
      高尾聖心, 清水伸一, 宮本直樹, 松浦妙子, 寅松千枝, 二本木英明, 山田貴啓, 梅垣菊男, 白土博樹
    • Organizer
      第10回日本粒子線治療臨床研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Baseline Shift of Intrafractional Lung Tumor Motionin a Real-time Tumor-tracking Radiotherapy2013

    • Author(s)
      Takao S, Miyamoto N, Matsuura T, Shimizu Onimaru R, Katoh N, Inoue T, and Shirato H
    • Organizer
      American Society for Radiation Oncology 55th Annual meeting
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] A Mathematical Framework to Select Fractionation Regimen based on Physical Dose Distribution for Proton Therapy2013

    • Author(s)
      Takao S, Mizuta M, Date H, Komiya Y, Sutherland KL, Onimaru R, Shimizu S, and Shirato H
    • Organizer
      52nd Annual Meeting of the Particle Therapy Co-Operative Group
    • Place of Presentation
      Essen
    • Related Report
      2013 Final Research Report
  • [Presentation] 陽子線治療における高精度位置決め用コーンビームCTの開発2013

    • Author(s)
      高尾聖心、清水伸一、宮本直樹、松浦妙子、寅松千枝、二本木英明、山田貴啓、梅垣菊男、白土博樹
    • Organizer
      第10回日本粒子線治療臨床研究会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Baseline Shift of Intrafractional Lung Tumor Motionin a Real-time Tumor-tracking Radiotherapy2013

    • Author(s)
      S,Takao S, Miyamoto N, Matsuura T, Shimizu Onimaru R, Katoh N, Inoue T, and Shirato H
    • Organizer
      ASTRO's 56th Annual Meeting
    • Place of Presentation
      アトランタ
    • Related Report
      2013 Annual Research Report
  • [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy, Applied Biological Engineering - Principles and Practice2012

    • Author(s)
      Takao S, Tadano S, Taguchi H, and Shirato H
    • Publisher
      Intech
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 放射線治療システム2013

    • Inventor(s)
      清水伸一, 高尾聖心, 宮本直樹, 松浦妙子, 梅川徹, 平本和夫, 馬場理香, 佐々木淑江, 長峯嘉彦
    • Industrial Property Rights Holder
      北海道大学, 株式会社日立製作所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-162656
    • Filing Date
      2013-08-05
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 放射線治療システム2013

    • Inventor(s)
      清水伸一、高尾聖心、宮本直樹、松浦妙子、梅川徹 他
    • Industrial Property Rights Holder
      北海道大学、株式会社日立製作所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-162656
    • Filing Date
      2013-08-05
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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