Quantification of Myocardial Blood Flow with Dynamic Perfusion 3.0 Tesla MRI

• Project/Area Number: 24791263
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: MANABE Osamu 北海道大学, 医学(系)研究科(研究院), 助教 (40443957)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: MRI / 心筋血流定量

Research Abstract

Our aim of this study was to develop and validate a method to quantify myocardial blood flow (MBF) with dynamic perfusion MRI (MBFMRI) at 3 Tesla (T) in comparison with MBF quantified by 15O-water PET (MBFPET). At first 10 healthy male volunteers underwent MRI and PET at rest and during adenosine triphosphate infusion. We estimated the extraction fraction of Gd-DTPA using K1 (inflow rate from time intensity curves) and MBF from 15O-water PET with the Renkin-Crone model. For the validation, MBFMRI was calculated from the other 10 subjects with the model established by pilot group and compared to MBFPET. The calculated MBFMRI showed excellent correlations with MBFPET not only in the whole heart, but also in the 3 regional per-vessel analyses.

Research Products

• [Journal Article] Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H 2O PET (2014)
  • Author(s): Yasuka Kikuchi, Noriko Oyama-Manabe, Masanao Naya, Osamu Manabe, Yuuki Tomiyama, Tsukasa Sasaki, Chietsugu Katoh, Kohsuke Kudo, Nagara Tamaki, Hiroki Shirato
  • Journal Title: Eur Radiol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Quantification of myocardial blood flow using dynamic 320-row multi-detector CTas compared with 15O-H2O PET (2014)
  • Author(s): Kikuchi Y, Oyama-Manabe N, Naya M, Manabe O, Tomiyama Y, Sasaki T, Katoh C, Kudo K, Tamaki N, Shirato H.
  • Journal Title: Eur Radiol Volume: 未定 Issue: 7 Pages: 1547-1556
  • DOI: 10.1007/s00330-014-3164-3
  • Peer Reviewed / Open Access
• [Presentation] Quantification of Myocardial Blood Flow with Dynamic Perfusion 3.0 Tesla MRI using Validation with <15>^O-water PET : Application to Regional Analysis (2014)
  • Author(s): Y. Tomiyama, O. Manabe, N.Oyama-Manabe, Y.Kikuchi, H.Sugimori, C. Katoh, N. Tamaki
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-14
• [Presentation] Quantification of Myocardial Blood Flow with Dynamic Perfusion 3.0 Tesla MRI using Validation with 15O-water PET : Application to Regional Analysis (2014)
  • Author(s): .Y. Tomiyama, O. Manabe, N.Oyama-Manabe, Y.Kikuchi,H.Sugimori, C. Katoh, N
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Quantification of Myocardial Blood Flow with 3.0 Tesla MRI perfusion image in healthy persons : Comparison with <15>^O-H2O PET (2012)
  • Author(s): Y. Tomiyama, C. Katoh, O. Manabe, N.Oyama-Manabe, K. Yoshinaga, N. Tamaki
  • Organizer: 59th Seminar of Nuclear Medicine
  • Place of Presentation: Florida
  • Year and Date: 2012-06-09
• [Presentation] <15>^O‐H2O 心筋PETを用いたMRI perfusion image による心筋血流定量法の評価 (2012)
  • Author(s): 富山勇輝, 加藤千恵次, 真鍋治, 真鍋徳子, 杉森博行, 吉永恵一郎
  • Organizer: 第68回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-10