| Project/Area Number |
24791266
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
HIROSE Katsumi 弘前大学, 医学(系)研究科(研究院), 助教 (60623767)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | ニトログリセリン / 放射線増感 / A549 / 低酸素細胞 / HIF-1a |
|---|
| Research Abstract |
We examined whether nitroglycerin (NTG), which is a effective vasodilator, have an influence on radiosensitivity of cancers through reoxygenation of tumor tissue. The concentration allowable to a livingbody of NTG presented no radiosensitivity in A549 cells, although NTG increased the expression of HIF1alpha and ATM proteins. This study suggested that intracellular reactive oxygen species, including nitric oxide induced by NTG, are involved with megakaryocytopoiesis of K562 chronic leukemia cells.
The administration of NTG just before irradiation of 10 Gy presented no radisensitivity on SAS tumor xenograft mouse model. However, NTG increased partial oxygen pressure of the tumor tissue slowly and transiently without the change of the tumor blood flow.
|
