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The study of radiosensitive effect through delatation of tumor vessels with nitroglycerin

Research Project

Project/Area Number 24791266
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHirosaki University

Principal Investigator

HIROSE Katsumi  弘前大学, 医学(系)研究科(研究院), 助教 (60623767)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsニトログリセリン / 放射線増感 / A549 / 低酸素細胞 / HIF-1a
Research Abstract

We examined whether nitroglycerin (NTG), which is a effective vasodilator, have an influence on radiosensitivity of cancers through reoxygenation of tumor tissue. The concentration allowable to a livingbody of NTG presented no radiosensitivity in A549 cells, although NTG increased the expression of HIF1alpha and ATM proteins. This study suggested that intracellular reactive oxygen species, including nitric oxide induced by NTG, are involved with megakaryocytopoiesis of K562 chronic leukemia cells.
The administration of NTG just before irradiation of 10 Gy presented no radisensitivity on SAS tumor xenograft mouse model. However, NTG increased partial oxygen pressure of the tumor tissue slowly and transiently without the change of the tumor blood flow.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Effects of radiation on the maturation of megakaryocytes.2013

    • Author(s)
      Hirose K, Monzen S, Yoshino H, Sato H, Aoki M, Hatayama Y, Kawaguchi H, Sato M, Narita Y, Takai Y, Kashiwakura I.
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Issue: 3 Pages: 447-452

    • DOI

      10.1093/jrr/rrs127

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate2012

    • Author(s)
      Katsumi Hirose
    • Journal Title

      Journal of Radiaiton Research

      Volume: - Issue: 3 Pages: 1-9

    • DOI

      10.1093/jrr/rrs125

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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