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Prospective study to investigate the role of nuclear medicine imaging in the early-detection of the radiation-induced heart disease

Research Project

Project/Area Number 24791267
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

Takanami Kentaro  東北大学, 大学病院, 助教 (90447160)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords放射腺心筋障害 / BMIPP / 放射線心筋障害 / FDG / PET
Outline of Final Research Achievements

The purpose of this study was to investigate the role of nuclear medicine imaging in the prediction of radiation-induced heart disease (RIHD). This study included 12 esophageal cancer patients who underwent SPECT/CT using I-123-labelled fatty acid analogue (BMIPP) at pre-chemoradiation therapy (CRT), pre-boost irradiation, 3-month post-CRT, and 1-year post-CRT. The correlations between radiation dose to the heart and the change of myocardial BMIPP uptake from pre-CRT (Δmyocardial BMIPP uptake) were assessed. As a result, at pre-boost and 3-month post-CRT, Δmyocardial BMIPP uptake was significantly correlated with radiation dose to LV and WH. However, there were no statistically significant correlations at 1-year post-CRT. The results of this study indicated that, in the long term after CRT, myocardial metabolism might affected by factors other than the radiation dose to the heart. Nuclear medicine imaging may provide additional information regarding RIHD.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT.2016

    • Author(s)
      Kentaro Takanami, Akira Arai, Rei Umezawa, Takashi Takeuchi, Noriyuki Kadoya, Yasuyuki, Keiichi Jingu, Kei Takase
    • Journal Title

      Radiotherapy and Oncology

      Volume: 119 Issue: 1 Pages: 77-83

    • DOI

      10.1016/j.radonc.2016.01.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Association between radiation dosimetry of the heart and the myocardial fatty acid metabolic impairment due to chemoradiation-therapy : Prospective study using I-123 BMIPP SPECT/CT2015

    • Author(s)
      Kentaro Takanami, Akira Arai, Rei Umezawa, Noriyuki Kadoya, Takashi Takeuchi, Keiichi Jingu, Kei Takase
    • Organizer
      European Association of Nuclear Medicine 2015
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食道癌化学放射線療法における心臓照射線量と心筋脂肪酸代謝障害の関連:BMIPP SPECT/CTによる経時的評価2015

    • Author(s)
      高浪健太郎、 荒井 晃、 梅澤 玲、 角谷倫之、 竹内孝至、 神宮啓一、 高瀬 圭
    • Organizer
      第81回日本心臓血管放射腺研究会
    • Place of Presentation
      札幌
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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