MRI-based morphological brain analysis in a rat model of Parkinson's disease and preclinical trials of neurotrophic factors

• Project/Area Number: 24791271
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: SUMIYOSHI AKIRA 東北大学, 加齢医学研究所, 助教 (80612530)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 神経科学 / ラット / VBM / 輪回し運動 / パーキンソン病 / MRI / 栄養因子 / ＭＲＩ

Outline of Final Research Achievements

Using the high-resolution T2-weighted bran images in rats, our laboratory developed the tissue prior probability maps that include the segmentations of gray matter, white matter, and cerebrospinal fluid. These tissue probability maps enable us to perform voxel-based morphometry (VBM) that has been widely used in human studies. We applied the VBM method to the rat models of Parkinson’s disease, wheel running exercise, cardiopulmonary resuscitation, and heart failure, exemplifying the utility of VBM method in the preclinical rodent studies.