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Radiation-induced HIF-1 alpha is associated with radiation resistance in glioblastoma cells.

Research Project

Project/Area Number 24791277
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

SHIRAI Katsuyuki  群馬大学, 医学(系)研究科(研究院), 講師 (10400748)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsHIF-1α / 神経膠芽腫 / radiation / HIF1α / 放射線抵抗性 / PDK-1 / 放射線抵抗腫瘍
Outline of Final Research Achievements

Glioblastoma is one of the most radioresistant tumors and the patients have poor prognosis. Hypoxia inducible factor-1α (HIF-1α), molecular markers of hypoxia, has been reported to be associated with radioresistance. We demonstrated that radiation-induced HIF-1α increases PDK1 expression in glioblastoma cells. In the future, this mechanism will be evaluated in vivo model.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Topics in chemotherapy, molecular-targeted therapy, and immunotherapy for newly-diagnosed glioblastoma multiforme.2015

    • Author(s)
      Okonogi N, Shirai K, Oike T, Murata K, Noda SE, Suzuki Y, Nakano T.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1229-1235

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dosimetric analysis between carbon ion radiotherapy and stereotactic body radiotherapy in stage I lung cancer.2014

    • Author(s)
      Ebara T, Shimada H, Kawamura H, Shirai K, Saito J, Kawashima M, Tashiro M, Ohno T, Kanai T, Nakano T.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 5099-5104

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the radiosensitivities of neurons and glial cells derived from the same rat brain.2014

    • Author(s)
      Kudo S, Suzuki Y, Noda SE, Mizui T, Shirai K, Okamoto M, Kaminuma T, Yoshida Y, Shirao T, Nakano T.
    • Journal Title

      Exp Ther Med.

      Volume: 8 Pages: 754-758

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons.2013

    • Author(s)
      Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-Jahdari WS, Chakravarti A, Shirao T, Nakano T.
    • Journal Title

      Radiat Res.

      Volume: なし

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognosis was not deteriorated by multiple primary cancers in esophageal cancer patients treated by radiotherapy.2013

    • Author(s)
      Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Ishikawa H, Nonaka T, Takahashi T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: なし

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of HIF-1α expression and radiation resistance in acute hypoxic conditions.2012

    • Author(s)
      Oike T, Suzuki Y, Al-Jahdari W, Mobaraki A, Saitoh JI, Torikai K, Shirai K, Nakano T.
    • Journal Title

      Exp Ther Med.

      Volume: 3 Pages: 141-145

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers.2012

    • Author(s)
      Shirai K, Nakagawa A, Abe T, Kawahara M, Saitoh J, Ohno T, Nakano T.
    • Journal Title

      Int J Mol Imaging.

      Volume: 2012 Pages: 609545-609545

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The Maximum Standardized Uptake Value (SUVmax) on FDG-PET Predicted Overall Survival and Progression Free Survival but not Local Control for Stage I Non-Small-Cell Lung Cancer Treated with Carbon Ion Radiotherapy.2014

    • Author(s)
      K. Shirai, T. Abe, J. Saitoh, Y. Takakusagi, S. Shiba, N. Okano, T. Ohno, T. Nakano.
    • Organizer
      ASTRO 56TH Annual meeting
    • Place of Presentation
      San-Francisco
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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