Radiation-induced HIF-1 alpha is associated with radiation resistance in glioblastoma cells.

• Project/Area Number: 24791277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: SHIRAI Katsuyuki 群馬大学, 医学(系)研究科(研究院), 講師 (10400748)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: HIF-1α / 神経膠芽腫 / radiation / HIF1α / 放射線抵抗性 / PDK-1 / 放射線抵抗腫瘍

Outline of Final Research Achievements

Glioblastoma is one of the most radioresistant tumors and the patients have poor prognosis. Hypoxia inducible factor-1α (HIF-1α), molecular markers of hypoxia, has been reported to be associated with radioresistance. We demonstrated that radiation-induced HIF-1α increases PDK1 expression in glioblastoma cells. In the future, this mechanism will be evaluated in vivo model.

Research Products

• [Journal Article] Topics in chemotherapy, molecular-targeted therapy, and immunotherapy for newly-diagnosed glioblastoma multiforme. (2015)
  • Author(s): Okonogi N, Shirai K, Oike T, Murata K, Noda SE, Suzuki Y, Nakano T.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 1229-1235
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dosimetric analysis between carbon ion radiotherapy and stereotactic body radiotherapy in stage I lung cancer. (2014)
  • Author(s): Ebara T, Shimada H, Kawamura H, Shirai K, Saito J, Kawashima M, Tashiro M, Ohno T, Kanai T, Nakano T.
  • Journal Title: Anticancer Res. Volume: 34 Pages: 5099-5104
  • Peer Reviewed
• [Journal Article] Comparison of the radiosensitivities of neurons and glial cells derived from the same rat brain. (2014)
  • Author(s): Kudo S, Suzuki Y, Noda SE, Mizui T, Shirai K, Okamoto M, Kaminuma T, Yoshida Y, Shirao T, Nakano T.
  • Journal Title: Exp Ther Med. Volume: 8 Pages: 754-758
  • Peer Reviewed
• [Journal Article] X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons. (2013)
  • Author(s): Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-Jahdari WS, Chakravarti A, Shirao T, Nakano T.
  • Journal Title: Radiat Res. Volume: なし
  • Peer Reviewed
• [Journal Article] Prognosis was not deteriorated by multiple primary cancers in esophageal cancer patients treated by radiotherapy. (2013)
  • Author(s): Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Ishikawa H, Nonaka T, Takahashi T, Nakano T.
  • Journal Title: J Radiat Res. Volume: なし
  • Peer Reviewed
• [Journal Article] Suppression of HIF-1α expression and radiation resistance in acute hypoxic conditions. (2012)
  • Author(s): Oike T, Suzuki Y, Al-Jahdari W, Mobaraki A, Saitoh JI, Torikai K, Shirai K, Nakano T.
  • Journal Title: Exp Ther Med. Volume: 3 Pages: 141-145
  • Peer Reviewed
• [Journal Article] Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers. (2012)
  • Author(s): Shirai K, Nakagawa A, Abe T, Kawahara M, Saitoh J, Ohno T, Nakano T.
  • Journal Title: Int J Mol Imaging. Volume: 2012 Pages: 609545-609545
  • Peer Reviewed
• [Presentation] The Maximum Standardized Uptake Value (SUVmax) on FDG-PET Predicted Overall Survival and Progression Free Survival but not Local Control for Stage I Non-Small-Cell Lung Cancer Treated with Carbon Ion Radiotherapy. (2014)
  • Author(s): K. Shirai, T. Abe, J. Saitoh, Y. Takakusagi, S. Shiba, N. Okano, T. Ohno, T. Nakano.
  • Organizer: ASTRO 56TH Annual meeting
  • Place of Presentation: San-Francisco
  • Year and Date: 2014-09-14 – 2014-09-17