Subtype classification of hepatocellular carcinoma by Gd-EOB-DTPA enhanced magnetic resonance imaging
| Project/Area Number |
24791281
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
KITAO Azusa 金沢大学, 大学病院, 助教 (20608690)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肝細胞癌 / subtype / MRI / Gd-EOB-DTPA / subtype分類 |
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| Research Abstract |
On the hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging (EOB-MRI), hepatocellular carcinoma (HCC) commonly shows hypointensity, however, a part of HCCs demonstrates hyperintensity caused by over-expression of OATP8, the uptake transporter of Gd-EOB-DTPA. We analyzed the correlation between the biological features and signal intensity on EOB-MRI in surgically resected HCC.
Hyperintense HCC showed significantly less malignant biological features and better prognosis than those of hypointense HCC. Hyperintense HCC, namely OATP8 over-expressed HCC, is supposed to be a subtype with mature hepatocyte like molecular backgrounds.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma.2014
Author(s)
Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
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Journal Title
Hepatology
Volume: in press
Issue: 5
Pages: 1674-85
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hypervascular hepatocellular carcinoma : correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images2012
Author(s)
Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Gabata T, Yamashita T, Kaneko S, Nakanuma Y, Kita R, Arii S
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Journal Title
Radiology
Volume: 265
Issue: 3
Pages: 780-9
DOI
Related Report
Peer Reviewed
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[Presentation] Hypervascular Hepatocellular Carcinoma Showing Hyperintensity on Hepatobiliary Phase of Gadoxetic Acid Enhanced MR Imaging: A Less Malignant Subtype with Low Production of AFP and PIVKA-II.2013
Author(s)
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Wataru Koda, Toshifumi Gabata, Tatsuya Yamashita, Shuichi Kaneko, Yasuni Nakanuma
Organizer
American Roentogen Ray Society Annual Meeting 2013
Place of Presentation
Marriott Wardman Park (Washington, USA)
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