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Hepatic cancer stem cell derived cancer: radiologic pathologic correlation

Research Project

Project/Area Number 24791283
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

KAZUO Kozaka  金沢大学, 医学系, 助教 (80547175)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords混合型肝癌 / 細胆管細胞癌 / CT / MRI / ステムセル由来癌 / 癌遺伝子 / 肝幹細胞由来癌 / 硬化型肝癌 / 中間型肝癌 / 癌ステムセル / 原発性肝癌
Outline of Final Research Achievements

Liver stem cell-derived liver cancer is classifiable into a typical, mixed, cholangiolocellular subtypes. These diagnostics, prognosis and treatment is not determined.
In this retrospective study, though we couldn't determine the specific findings in typical and mixed type, we could reveal that cholangiolocellular subtype showed characteristic findings on dynamic CT/MRI and low accumulation of FDG compared with ordinaly cholangiocellular carcinoma. Furthermore there were different cancer gene expressions between cholangiolocellular subtype and intrahepatic cholangiocellular carcinoma. We believe that cholangiolocellular subtype is unique and it should be considered as a independent disease from ordinary cholangiocellular carcinoma.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 Other

All Journal Article (4 results) Presentation (13 results) (of which Invited: 5 results)

  • [Journal Article] 【正常と異常の境界:初期病変を画像診断でとらえる】 肝細胞癌 前癌病変から早期肝癌の画像所見2013

    • Author(s)
      小坂一斗
    • Journal Title

      臨床画像

      Volume: 29 Pages: 1102-1111

    • Related Report
      2013 Research-status Report
  • [Journal Article] 癌の術後画像診断-合併症と局所再発のチェックポイント-2013

    • Author(s)
      小坂一斗
    • Journal Title

      画像診断

      Volume: 33 Pages: 136-149

    • Related Report
      2013 Research-status Report
  • [Journal Article] 【粘液産生性胆道系腫瘍の再出発-エビデンスとしての画像と病理】 IPNBの画像診断と粘液産生2013

    • Author(s)
      小坂一斗
    • Journal Title

      胆と膵

      Volume: 34 Pages: 381-387

    • Related Report
      2013 Research-status Report
  • [Journal Article] 肝内胆道系悪性腫瘍の画像診断 充実性腫瘍2013

    • Author(s)
      小坂一斗
    • Journal Title

      臨床放射線

      Volume: 58 Pages: 263-272

    • Related Report
      2012 Research-status Report
  • [Presentation] Peritumoral enhancement of hepatic tumors and tumorous lesions -Analysis based on the hemodynamics evaluated by angiography-assisted CT and histopathology-2014

    • Author(s)
      Kazuto Kozaka
    • Organizer
      Radiology society of North America
    • Place of Presentation
      Chicago, McCormick Place
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unclassified hepatocellular nodule in the cirrhosis: A nodule with doughnut-like appearance on hepatobiliary phase of Gd-EOB DTPA enhanced MRI and portal venous supply: A retrospective study -its prevalence, prognosis and pathology2014

    • Author(s)
      Kazuto Kozaka
    • Organizer
      The 15th Asian Oceanian Congress of Radiology
    • Place of Presentation
      Kobe,Kobe International Conference Center
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] IPNBのCT/MRI画像所見と鑑別疾患2014

    • Author(s)
      小坂一斗
    • Organizer
      胆道学会
    • Place of Presentation
      エーザイ本館, 東京都
    • Year and Date
      2014-08-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「肝細胞癌と鑑別を要する疾患」2014

    • Author(s)
      小坂一斗
    • Organizer
      第33回日本画像医学会
    • Place of Presentation
      東京ステーションコンファランス
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 皮下結節性脂肪壊死症を契機に診断された巨大肝転移を伴う膵腺房細胞癌の1例2013

    • Author(s)
      小坂一斗
    • Organizer
      第27回 日本腹部放射線研究会
    • Place of Presentation
      宇都宮東部ホテルグランデ
    • Related Report
      2013 Research-status Report
  • [Presentation] Combined hepatocellular cholangiocarcinoma, subtype with stem-cell feature: Imaging analysis of angiography assisted CT

    • Author(s)
      Kazuto Kozaka
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Imaging findings of cystic biliary disease

    • Author(s)
      Kazuto Kozaka
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 膵癌術後画像の撮像法と診断のポイント

    • Author(s)
      小坂一斗
    • Organizer
      第49回 Radiology Update学術講演会
    • Place of Presentation
      東京コンファレンスセンター品川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Early peritumoral enhancement of bile ductular carcinoma: radiologic-pathologic correlation

    • Author(s)
      Kazuto Kozaka
    • Organizer
      北米放射線学会
    • Place of Presentation
      McCormick Place, Chicago, America
    • Related Report
      2012 Research-status Report
  • [Presentation] Hyper-Intense nodules on Hepatobiliary phase of Gd-EOB-DTPA with preserved portal supply in chronic advanced hepatitis: Imaging characteristics and Follow up observation

    • Author(s)
      Kazuto Kozaka
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 胆管付属腺に沿って発育した肝内胆管癌の一例

    • Author(s)
      小坂一斗
    • Organizer
      第25回日本腹部放射線研究会
    • Place of Presentation
      ホテルエルセラーン大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵管・胆管の粘液産生性乳頭状腫瘍と粘液性嚢胞性腫瘍のMR診断

    • Author(s)
      小坂一斗
    • Organizer
      第40回日本磁気共鳴医学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] びまん性肝疾患②肝内胆道疾患

    • Author(s)
      小坂一斗
    • Organizer
      第48回日本医学放射線学会 秋季臨床大会
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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