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Enhancing anti-tumor effect of I-131 MIBG therapy for neuroblastoma by inhibition of cell recovery

Research Project

Project/Area Number 24791285
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

WAKABAYASHI Hiroshi  金沢大学, 大学病院, 助教 (60622818)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経芽腫 / 内用療法 / カフェイン / 131I-MIBG
Research Abstract

I-131 meta-iodobenzylguanidine (MIBG) has been used to treat patients with high-risk neuroblastoma. I-131 MIBG accumulate into tumor cells and has an anti-tumor effect by high-energy beta-irradiation. Caffeine is classified as purine alkaloids, and has anti-tumor effect in tumor cells by inhibition of DNA-repair. This study was performed whether I-131 MIBG interacted with caffeine for human neuroblastoma cell line SK-N-SH. Cells were treated with caffeine at concentrations as high as 40 mM, and the anti-tumor effect of caffeine was concentrate-dependent. However, uptake of I-131 MIBG into neuroblastoma cells treated by caffeine was reduced independently of the load timing. These results suggest that high-dose caffeine has anti-tumor effect, but the anti-tumor effect by combined I-131 MIBG and caffeine will not be enhanced, probably by decreasing uptake of I-131 MIBG.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2013 2012

All Presentation (10 results) (of which Invited: 1 results)

  • [Presentation] RI療法今後の展開「I-131 MIBG」2013

    • Author(s)
      萱野大樹, 稲木 杏吏, 若林 大志, 赤谷 憲一, 福岡 誠, 絹谷 清剛
    • Organizer
      第53回日本核医学総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2013-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経芽腫内照射療法におけるカフェイン併用抗腫瘍効果の基礎的検討2013

    • Author(s)
      若林 大志, 萱野 大樹, 稲木 杏吏, 滝 淳一, 福岡 誠, 絹谷 清剛, 小林正和, 柴 和弘
    • Organizer
      第53回日本核医学総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経芽腫のI-131 MIBG療法におけるカフェイン併用抗腫瘍効果の基礎的検討2013

    • Author(s)
      若林 大志, 萱野 大樹, 稲木 杏吏, 滝 淳一, 福岡 誠, 絹谷 清剛, 小林正和, 柴 和弘
    • Organizer
      第77回日本核医学会中部地方会
    • Place of Presentation
      金沢大学医学類(金沢)
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経芽腫に対するI-131 MIBG治療の急性期副作用2013

    • Author(s)
      萱野大樹, 若林 大志, 稲木 杏吏, 虎谷 文音, 福岡 誠, 絹谷 清剛
    • Organizer
      第77回日本核医学会中部地方会
    • Place of Presentation
      金沢大学医学類(金沢)
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経芽腫内照射療法におけるカフェイン併用抗腫瘍効果の基礎的検討2013

    • Author(s)
      若林 大志、萱野 大樹、稲木 杏吏、滝 淳一、福岡 誠、絹谷 清剛、小林 正和、柴 和弘
    • Organizer
      第53回日本核医学総会
    • Place of Presentation
      福岡国際会議場( 福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RI内用療法の今後の展開 「I-131 MIBG」2013

    • Author(s)
      萱野大樹、稲木 杏吏、若林 大志、赤谷 憲一、福岡 誠、絹谷 清剛
    • Organizer
      第53回日本核医学総会
    • Place of Presentation
      福岡国際会議場( 福岡)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経芽腫のI-131 MIBG療法におけるカフェイン併用抗腫瘍効果の基礎的検討2013

    • Author(s)
      若林 大志、萱野 大樹、稲木 杏吏、滝 淳一、福岡 誠、絹谷 清剛、小林 正和、柴 和弘
    • Organizer
      第77回日本核医学会中部地方会
    • Place of Presentation
      金沢大学医学類( 金沢)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経芽腫に対するI-131 MIBG治療の急性期副作用2013

    • Author(s)
      萱野 大樹、若林 大志、稲木 杏吏、虎谷 文音、福岡 誠、絹谷 清剛
    • Organizer
      第77回日本核医学会中部地方会
    • Place of Presentation
      金沢大学医学類( 金沢)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The prognostic value of hormonal response after initial low-dose I-131 MIBG therapy in patients with malignant pheocytoma and paraganglioma2012

    • Author(s)
      Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Ayane Nakamura, Daiki Kayano, Makoto Fukuoka, Shinro Matsuo, Kenichi Nakajima, Seigo Kinuya
    • Organizer
      EANM congress 2012
    • Place of Presentation
      Milano Congressi (Italy)
    • Year and Date
      2012-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The Prognostic Value of Hormonal Responses after Initial Low Dose I-131 MIBG Therapy in Patients with Malignant Pheochromocytoma and Paraganglioma2012

    • Author(s)
      H. Wakabayashi, J. Taki, A. Inaki, A. Nakamura, D. Kayano, M. Fukuoka, S. Matsuo, K. Nakajima, S. Kinuya
    • Organizer
      EANM Congress 2012
    • Place of Presentation
      Milano Congressi (Italy)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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