Breakthrough of normal pharmacokinetics of human inner ear using magnetic resonance imaging after intravenous gadolinium injection

• Project/Area Number: 24791288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: YAMAZAKI Masahiro 名古屋大学, 医学部附属病院, 病院助教 (40595526)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 磁気共鳴画像法 / 内耳の生理的薬物動態 / Heavily T2強調3D-FLAIR / ガドリニウム造影剤 / 放射線医学 / 頭部の種々の液体の生理的動態

Outline of Final Research Achievements

Magnetic resonance imaging after intravenous gadolinium injection enable visualization of endolymphatic hydrops of inner ear. However, normal pharmacokinetics of gadolinium injected intravenously in the inner ear is still unclear. The purpose of this study is to make it clear.
In the present study, heavily T2-weighted 3D-FLAIR images of healthy volunteers were obtained on pre- and post-contrast several time points. Based on these imaging data, we revealed the pharmacokinetics of gadolinium injected intravenously in the inner ear perilymph.

Research Products

• [Journal Article] Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol (2014)
  • Author(s): Naganawa S, Suzuki K, Yamazaki M, Sakurai Y, Ikeda M.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 13 Issue: 2 Pages: 73-80
  • DOI: 10.2463/mrms.2013-0080
  • NAID: 130003393001
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MR Imaging of Ménière’s Disease after Combined Intratympanic and Intravenous Injection of Gadolinium using HYDROPS2 (2014)
  • Author(s): Shinji Naganawa, Masahiro Yamazaki, Hisashi Kawai, Kiminori Bokura, Tatsuo Iida, Michihiko Sone, Tsutomu Nakashima
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 13 Issue: 2 Pages: 133-137
  • DOI: 10.2463/mrms.2013-0061
  • NAID: 130003392999
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of brain white matter tracts using heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery magnetic resonance imaging. (2014)
  • Author(s): YAMAZAKI Masahiro, NAGANAWA Shinji, BOKURA Kiminori, KAWAI Hisashi
  • Journal Title: Nagoya J Med Sci Volume: 76 Pages: 285-291
  • NAID: 120005468126
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serial Scans in Healthy Volunteers Following Intravenous Administration of Gadoteridol: Time Course of Contrast Enhancement in Various Cranial Fluid Spaces (2014)
  • Author(s): NAGANAWA Shinji, SUZUKI Kojiro, YAMAZAKI Masahiro, SAKURAI Yasuo
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 13 Issue: 1 Pages: 7-13
  • DOI: 10.2463/mrms.2013-0056
  • NAID: 130003392991
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: Does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts? (2014)
  • Author(s): Masahiro Yamazaki, Shinji Naganawa, Hisashi Kawai, Mitsuru Ikeda, Kiminori Bokura, Haruo Isoda, Tsutomu Nakashima
  • Journal Title: PLoS ONE Volume: 9(3) Issue: 3 Pages: e91860-e91860
  • DOI: 10.1371/journal.pone.0091860
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections. (2013)
  • Author(s): IIDA Tatsuo, TERANISHI Masaaki, YOSHIDA Tadao, OTAKE Hironao, SONE Michihiko, KATO Masahiro, SHIMONO Mariko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 5 Pages: 434-438
  • DOI: 10.3109/00016489.2012.753640
  • Peer Reviewed
• [Journal Article] Visualization of Endolymphatic Hydrops in Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide at 1.5T (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 2 Pages: 137-139
  • DOI: 10.2463/mrms.2012-0037
  • NAID: 10031183927
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Three-dimensional Visualization of Endolymphatic Hydrops after Intravenous Administration of Single-dose Gadodiamide (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 2 Pages: 147-151
  • DOI: 10.2463/mrms.2012-0050
  • NAID: 10031183929
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Estimation of Perilymph Enhancement after Intratympanic Administration of Gd-DTPA by Fast T₁-mapping with a Dual Flip Angle 3D Spoiled Gradient Echo Sequence (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 3 Pages: 223-228
  • DOI: 10.2463/mrms.2012-0071
  • NAID: 10031201760
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Endolymphatic hydrops in patients with tinnitus as the major symptom. (2013)
  • Author(s): Tadao Yoshida, Masaaki Teranishi, Masahiro Kato, Hironao Otake, Ken Kato, Michihiko Sone, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 270(12) Issue: 12 Pages: 3043-3048
  • DOI: 10.1007/s00405-013-2380-9
  • Peer Reviewed
• [Journal Article] Establishing Normal Diameter Range of the Cochlear and Facial Nerves with 3D-CISS at 3T (2013)
  • Author(s): NAKAMICHI Rei, YAMAZAKI Masahiro, IKEDA Mitsuru, ISODA Haruo, KAWAI Hisashi, SONE Michihiko, NAKASHIMA Tsutomu, NAGANAWA Shinji
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 4 Pages: 241-247
  • DOI: 10.2463/mrms.2013-0004
  • NAID: 130003383918
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection. (2013)
  • Author(s): Yamazaki M
  • Journal Title: Neuroradiology. Volume: 54 Issue: 10 Pages: 1161-1169
  • DOI: 10.1007/s00234-012-1078-9
  • Peer Reviewed
• [Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere’s disease. (2013)
  • Author(s): KATO Masahiro, SUGIURA Makoto, SHIMONO Mariko, YOSHIDA Tadao, OTAKE Hironao, KATO Ken, TERANISHI Masaaki, SONE Michihiko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 2 Pages: 123-129
  • DOI: 10.3109/00016489.2012.726374
  • Peer Reviewed
• [Journal Article] Imaging of Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Multiplication of MR Cisternography and HYDROPS Image (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 1 Pages: 63-68
  • DOI: 10.2463/mrms.2012-0027
  • NAID: 10031163464
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection. (2012)
  • Author(s): YAMAZAKI Masahiro, NAGANAWA Shinji, TAGAYA Mitsuhiko, KAWAI Hisashi, IKEDA Mitsuru, SONE Michihiko, TERANISHI Masaaki, SUZUKI Hirokazu, NAKASHIMA Tsutomu
  • Journal Title: AJNR Am J Neuroradiol Volume: 33 Issue: 4 Pages: 773-778
  • DOI: 10.3174/ajnr.a2821
  • Peer Reviewed
• [Journal Article] Imaging of Endolymphatic and Perilymphatic Fluid after Intravenous Administration of Single-dose Gadodiamide (2012)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 11 Issue: 2 Pages: 145-150
  • DOI: 10.2463/mrms.11.145
  • NAID: 10030799981
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Imaging of Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Subtraction Images with Different Inversion Time (2012)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 11 Issue: 3 Pages: 213-219
  • DOI: 10.2463/mrms.11.213
  • NAID: 10031046949
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Imaging of Ménière's Disease by Subtraction of MR Cisternography from Positive Perilymph Image (2012)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 11 Issue: 4 Pages: 303-309
  • DOI: 10.2463/mrms.11.303
  • NAID: 10031145231
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Presentation] Excretory MR pancreatography after intravenous administration of gadoteridol: Preliminary results in eight healthy volunteers. (2014)
  • Author(s): SUZUKI Kojiro, NAGANAWA Shinji, FURUHASHI Naohiro, HYODO Ryota, YAMAZAKI Masahiro
  • Organizer: European Congress of Radiology (ECR) 2014
  • Place of Presentation: Vienna, Austria
• [Presentation] Objective diagnosis of Meniere’s disease by clinically applicable method: How to do it (メニエール病のMRIによる簡便な客観診断法；How to do it) (2013)
  • Author(s): 長縄慎二、山崎雅弘、川井恒、中島務
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜 (横浜市)
• [Presentation] MR imaging of Meniere’s disease by intratympanic (IT) and intravenous (IV) injection of Gd-DTPA: Double contrast injection and a novel imaging strategy, HYDROPS2 for IT+IV. (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu
  • Organizer: International Society of Magnetic Resonance in Medicine (ISMRM) 21st Annual Meeting and Exhibition
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Heavily T2-weighted 3D-FLAIRを用いた白質線維描出: 静注Gd遅延造影は白質線維描出能に影響を与えるか？ (2013)
  • Author(s): 山崎雅弘、長縄慎二、川井恒、池田充、卜蔵公紀、礒田治夫、中島務
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: アスティ徳島 (徳島市)
• [Presentation] Visualization of white matter tracts using a non-DWI method: Does intravenous gadolinium injection four hours prior to the examination affect the degree of visualization of white matter tracts? (2013)
  • Author(s): YAMAZAKI Masahiro, NAGANAWA Shinji, KAWAI Hisashi, IKEDA Mitsuru, BOKURA Kiminori, ISODA Haruo, NAKASHIMA Tsutomu
  • Organizer: European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 30th Annual Scientific Meeting
  • Place of Presentation: Toulouse, France
• [Presentation] Visualization of central nerve tracts using a non-EPI, non-DWI method. (2013)
  • Author(s): YAMAZAKI Masahiro, NAGANAWA Shinji, BOKURA Kiminori, KAWAI Hisashi
  • Organizer: European Congress of Radiology (ECR) 2013
  • Place of Presentation: Vienna, Austria
• [Presentation] Clinically applicable objective diagnosis of Meniere's disease by MR: How “to do” it. (2013)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, NAKASHIMA Tsutomu
  • Organizer: European Congress of Radiology (ECR) 2013
  • Place of Presentation: Vienna, Austria
• [Presentation] Fast T1-mapping用3D-GREシークエンスによる鼓室内Gd投与後の造影効果推定 (2012)
  • Author(s): 長縄慎二、山崎雅弘、中島務、川井恒
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Estimation of perilymph enhancement after intrarympanic administration of Gd-DTPA by fast T1-mapping with dual flip angle 3D-spoiled gradient echo sequence. (2012)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, NAKASHIMA Tsutomu
  • Organizer: International Society of Magnetic Resonance in Medicine (ISMRM) 20th Annual Meeting and Exhibition
  • Place of Presentation: Melbourne, Australia
• [Presentation] 拡散強調によらない脳幹神経束の描出の試み (2012)
  • Author(s): 卜蔵公紀、長縄慎二、山崎雅弘、川井恒、櫻井康雄、石橋一都、森美奈子、榊原勝浩、中野智、松岡祐樹、安藤康生、小西伊佐美、丸山裕輝
  • Organizer: 第2回Advanced CT・MR研究会
  • Place of Presentation: 軽井沢プリンスホテルウェスト（軽井沢）
• [Presentation] Heavily T2強調3D-FLAIRによる中枢神経路描出 (2012)
  • Author(s): 山崎雅弘、長縄慎二、卜蔵公紀、川井恒
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] 等倍量静注Gdによるメニエール病の内リンパ水腫描出；外リンパ陽性画像からT2強調画像の差分の有用性 (2012)
  • Author(s): 長縄慎二、山崎雅弘、川井恒、卜蔵公紀、櫻井康雄、曾根三千彦、中島務
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] Magnetic resonance imaging of the inner ear after intratympanic and intravenous gadolinium injections. (2012)
  • Author(s): NAKASHIMA Tsutomu, IIDA Tatsuo, TERANISHI Masaaki, YOSHIDA Tadao, KATO Masahiro, SONE Michihiko, YAMAZAKI Masahiro, NAGANAWA Shinji
  • Organizer: Inner Ear Biology Workshop and Symposium 2012
  • Place of Presentation: Tubingen, Germany
• [Presentation] Objective diagnosis of Meniere’s disease by clinically applicable MRI method: How “to do” it. (2012)
  • Author(s): NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, NAKASHIMA Tsutomu
  • Organizer: Radiological Society of North America (RSNA) 98th Scientific Assembly and Annual Meeting
  • Place of Presentation: Chicago, USA
• [Remarks] 名古屋大学 放射線医学教室
  • URL: http://www.med.nagoya-u.ac.jp/rad/
• [Remarks] 名古屋大学 教員データベースシステム
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100005957_ja.html
• [Remarks] 名古屋大学 放射線医学教室
  • URL: http://www.med.nagoya-u.ac.jp/rad/sub2.html
• [Remarks] 名古屋大学 教員データベースシステム
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100005957_ja.html