Breakthrough of normal pharmacokinetics of human inner ear using magnetic resonance imaging after intravenous gadolinium injection
Project/Area Number |
24791288
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 磁気共鳴画像法 / 内耳の生理的薬物動態 / Heavily T2強調3D-FLAIR / ガドリニウム造影剤 / 放射線医学 / 頭部の種々の液体の生理的動態 |
Outline of Final Research Achievements |
Magnetic resonance imaging after intravenous gadolinium injection enable visualization of endolymphatic hydrops of inner ear. However, normal pharmacokinetics of gadolinium injected intravenously in the inner ear is still unclear. The purpose of this study is to make it clear. In the present study, heavily T2-weighted 3D-FLAIR images of healthy volunteers were obtained on pre- and post-contrast several time points. Based on these imaging data, we revealed the pharmacokinetics of gadolinium injected intravenously in the inner ear perilymph.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere’s disease.2013
Author(s)
KATO Masahiro, SUGIURA Makoto, SHIMONO Mariko, YOSHIDA Tadao, OTAKE Hironao, KATO Ken, TERANISHI Masaaki, SONE Michihiko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu
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Journal Title
Acta Otolaryngol
Volume: 133
Issue: 2
Pages: 123-129
DOI
Related Report
Peer Reviewed
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