Clinical application of the four-dimensional radiation treatment planning

• Project/Area Number: 24791295
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MIYABE Yuki 京都大学, 医学(系)研究科(研究院), 講師 (60522505)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線治療 / 4次元治療計画 / 呼吸性移動 / 非剛体レジストレーション / Deformable registration / ４次元治療計画

Outline of Final Research Achievements

Accuracy of respiratory motion management in radiotherapy treatment planning was investigated. Clinical data of patients undergoing stereotactic body radiotherapy was analyzed, and the largest positional error (maximum 9.9 mm) was observed in deformable image registration(DIR). The DIR is a fundamental task in 4D dose calculation. It provides soft tissue alignment between different image sets where the organ motion exists. The results of this study indicated that DIR performance on each patient should be assessed. For clinical application of 4D treatment planning, a quality assurance tool designed to check the DIR accuracy easily was developed.

Research Products

• [Journal Article] Deformable image registrationを用いた４次元線量計算における肺体積変化の影響 (2012)
  • Author(s): 宮部結城、澤田 晃、石原佳知、溝脇尚志、平岡真寛
  • Journal Title: 医学物理 Volume: Vol.32 Sup.3 Pages: 157-158
• [Presentation] Development of quality assurance tool for deformable image registration (2014)
  • Author(s): Yuki Miyabe
  • Organizer: 4D Treatment Planning Workshop 2014
  • Place of Presentation: London, UK
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] Verification of deformable image registration in the 4D radiation treatment planning for abdominal organs (2014)
  • Author(s): Yuki Miyabe
  • Organizer: 14th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Ho Chi Minh City, Vietnam
  • Year and Date: 2014-10-23 – 2014-10-25
• [Presentation] Treatment verification using EPID cine images for dynamic tumor-tracking irradiation (2014)
  • Author(s): Yuki Miyabe
  • Organizer: 13th International Conference on Electronic Patient Imaging
  • Place of Presentation: Aarhus, Denmark
  • Year and Date: 2014-08-31 – 2014-09-03
• [Presentation] Impact on dose accumulation using a deformable image registration technique for 4D radiotherapy (2013)
  • Author(s): Yuki Miyabe
  • Organizer: International Conference on the Use of Computers in Radiation Therapy
  • Place of Presentation: Melbourne, Australia
• [Presentation] 腹部領域の４次元治療計画におけるDeformable image registrationの精度検証 (2013)
  • Author(s): 宮部結城
  • Organizer: 第26回日本放射線腫瘍学会学術大会
  • Place of Presentation: 青森
• [Presentation] Impact on dose accumulation using a deformable image registration technique for 4D radiotherapy (2013)
  • Author(s): Yuki Miyabe
  • Organizer: International Conference on the Use of Computers in Radiation Therapy 2013
  • Place of Presentation: Melbourne Convention and Exhibition Centre (Melbourne, Australia)
• [Presentation] Deformable image registrationを用いた４次元線量計算における肺体積変化の影響 (2012)
  • Author(s): 宮部結城
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば国際会議場(つくば)