Application of high-speed and high-precision denoising techniques with GPGPU for brain imaging

• Project/Area Number: 24791296
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: OISHI Naoya 京都大学, 医学(系)研究科(研究院), 助教 (40526878)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脳画像 / ノイズ除去 / GPGPU / MRI / PET / 脳 / non-local means

Outline of Final Research Achievements

A non-local means (NLM) filter has been proposed, which can effectively remove noise with preserving edge in return for computational burden. We have therefore developed an accelerating software of the 3D NLM filter by general-purpose graphics processing units (GPGPU), which enables massively parallel computing. In the study, we applied the software to human and animal brain MRI and demonstrated that it is useful not only for basic but also clinical researches.

Research Products

• [Journal Article] The Uncinate Fasciculus as a Predictor of Conversion from aMCI to Alzheimer Disease (2015)
  • Author(s): Hiyoshi-Taniguchi K, Oishi N, Namiki C, Miyata J, Murai T, Cichocki A, Fukuyama H
  • Journal Title: J Neuroimaging Volume: in press Issue: 5 Pages: 748-753
  • DOI: 10.1111/jon.12196
  • Peer Reviewed
• [Journal Article] Functional relevance of the precuneus in verbal politeness. (2015)
  • Author(s): Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G, Kawada R, Takahashi H, Murai T, Fukuyama H.
  • Journal Title: Neurosci Res. Volume: 91 Pages: 48-56
  • DOI: 10.1016/j.neures.2014.10.009
  • NAID: 120005593691
  • Peer Reviewed / Open Access
• [Journal Article] Freezing of gait and white matter changes: a tract-based spatial statistics study (2015)
  • Author(s): Iseki K, Fukuyama H, Oishi N, Tomimoto H, Otsuka Y, Nankaku M, Benninger D, Hallett M, Hanakawa T
  • Journal Title: J Clin Mov Disord Volume: in press Issue: 1 Pages: 1-9
  • DOI: 10.1186/s40734-014-0011-2
  • Peer Reviewed / Open Access
• [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury (2015)
  • Author(s): Walid Y, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K
  • Journal Title: J Clin Sleep Med Volume: in press
  • Peer Reviewed
• [Journal Article] Relation between Healthy Factors and the Adolescent Impulsiveness Scale (AIS) among Junior and Senior High School Students (2014)
  • Author(s): Moriguchi Y., Murai T., Oishi N., Fukuyama H
  • Journal Title: The Asian Journal of Child Care Volume: 5 Pages: 35-39
  • Peer Reviewed
• [Journal Article] Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging (2014)
  • Author(s): Suzuki T, Oishi N, Fukuyama H
  • Journal Title: Proceedings of the 2014 IEEE International Conference on Complex Medical Engineering Volume: 1 Pages: 214-219
  • Peer Reviewed
• [Journal Article] Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease (2014)
  • Author(s): Isaias I, Spiegel J, Brumberg J, Cosgrove KP, Marotta G, Oishi N, Higuchi T, Kusters S, Schiller M, Dillmann U, Van Dyck C, Buck A, Herrmann K, Schloegl S, Volkmann J, Lassmann M, Fassbender K, Lorenz R, Samnick S
  • Journal Title: Front. Aging Neurosci. Volume: 6 Pages: 160-160
  • Peer Reviewed / Open Access
• [Journal Article] Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading (2014)
  • Author(s): Inano Rika, Oishi Naoya, Kunieda Takeharu, Arakawa Yoshiki, Yamao Yukihiro, Shibata Sumiya, Kikuchi Takayuki, Fukuyama Hidenao, Miyamoto Susumu
  • Journal Title: NeuroImage: Clinical Volume: 5 Pages: 396-407
  • DOI: 10.1016/j.nicl.2014.08.001
  • NAID: 120005477685
  • Peer Reviewed / Open Access
• [Journal Article] Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase (2014)
  • Author(s): Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M
  • Journal Title: Stroke Volume: 45 Issue: 11 Pages: 3403-3411
  • DOI: 10.1161/strokeaha.114.006265
  • Peer Reviewed
• [Journal Article] アルツハイマー型認知症の評価－C-11 PiB PETなどによるアミロイドイメージング (2014)
  • Author(s): 大石直也、福山秀直
  • Journal Title: INNERVISION Volume: 29 Pages: 100-102
• [Journal Article] Relation between Healthy Factors and the Adolescent Impulsiveness Scale (AIS) among Junior and Senior High School Students (2014)
  • Author(s): Moriguchi Y, Murai T, Oishi N, Fukuyama H
  • Journal Title: The Asian Journal of Child Care Volume: in press
  • Peer Reviewed
• [Journal Article] A comparison of three brain atlases for MCI prediction. (2013)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H.
  • Journal Title: J Neurosci Methods. Volume: 221 Pages: 139-150
  • DOI: 10.1016/j.jneumeth.2013.10.003
  • Peer Reviewed
• [Journal Article] Temporal Lobe Epilepsy with Amygdala Enlargement: A Morphologic and Functional Study. (2012)
  • Author(s): Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
  • Journal Title: Journal of Neuroimaging Volume: 24 Issue: 1 Pages: 54-62
  • DOI: 10.1111/j.1552-6569.2011.00694.x
  • Peer Reviewed
• [Journal Article] A Challenge to Diffuse Optical Tomography using the Radiative Transport Equation (2012)
  • Author(s): Oishi N, Fukuyama H
  • Journal Title: Proceedings of the 2012 IEEE International Conference oD Complex Medical Engineering Volume: 1 Pages: 261-266
  • DOI: 10.1109/iccme.2012.6275595
  • Peer Reviewed
• [Journal Article] 認知症診断におけるマルチモーダルアプローチ①MRIのVBM (2012)
  • Author(s): 大石直也
  • Journal Title: Cognition and Dementia Volume: 11 Pages: 99-105
• [Presentation] MCIからADへの移行予測向上を目指して－灰白質・白質構造変化を用いた検討－ (2014)
  • Author(s): 大石直也、並木千尋、福山秀直
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] ラット脳のVoxel-based MorphometryにおけるNon-local Meansノイズ除去フィルタの効果 (2014)
  • Author(s): 大石直也、吉井崇喜、福山秀直
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Structural MRI for early diagnosis of dementia (2014)
  • Author(s): Naoya Oishi
  • Organizer: International Conference on Complex Medical Engineering 2014
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-06-26 – 2014-06-29
  • Invited
• [Presentation] 自己組織化マップと局所脳血流に基づく脳梗塞の層別化と認知機能の関連 (2014)
  • Author(s): 大石直也、中奥由里子、長谷佳樹、猪原匡史、福山秀直
  • Organizer: 第55回日本神経学会総会
  • Place of Presentation: 博多
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] 自己組織化マップと局所脳血流に基づく脳梗塞の層別化と認知機能の関連 (2014)
  • Author(s): 大石直也、中奥由里子、長谷佳樹、猪原匡史、福山秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台
• [Presentation] MCIにおける脳糖代謝分布パターンの多様性とADへの移行予測に関する検討 (2013)
  • Author(s): 大石直也、伊藤健吾、福山秀直
  • Organizer: 第54回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 自己組織化マップと局所脳血流に基づく脳梗塞の層別化と認知機能の関連 (2013)
  • Author(s): 大石直也、中奥由里子、長谷佳樹、猪原匡史、福山秀直
  • Organizer: 第18回認知神経科学会学術集会
  • Place of Presentation: 東京
• [Presentation] MCI脳糖代謝分布パターンの多様性解析とADへの移行予測 (2013)
  • Author(s): 大石直也、伊藤健吾、福山秀直
  • Organizer: 第32回日本認知症学会学術集会
  • Place of Presentation: 松本
• [Presentation] Predicting Alzheimer’s disease using a voxel-based approach: A comparison of three different atlases (2013)
  • Author(s): Kenichi Ota, Naoya Oishi, Kengo Ito, Hidenao Fukuyama
  • Organizer: Organization for Human Brain Mapping 2013
  • Place of Presentation: Seattle, USA
• [Presentation] Numerical Computations of Stationary Radiative Transport Equation with Optical Properties of Human Brains (2013)
  • Author(s): Hiroshi Fujiwara, Naoya Oishi
  • Organizer: The 9th East Asia SIAM Conference & The 2nd Conference on Industrial and Applied Mathematics (EASIAM-CIAM) 2013
  • Place of Presentation: Bandung, Indonesia
• [Presentation] A Novel Rat Model of Subcortical Ischemic Vascular Dementia with Ameroid Constrictor (2013)
  • Author(s): Kitamura A, Oishi N, Kalaria RN, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
  • Organizer: The 6th Congress of The International Society for Vascular Behavioral and Cognitive Disorders
  • Place of Presentation: Tronto, Canada
• [Presentation] Montreal Cognitive Assessment Score Correlates with Regional Cerebral Blood Flow in Post-stroke Patients (2013)
  • Author(s): Yuriko Nakaoku, Yoshiki Hase, Naoya Oishi, Tatsuo Manabe, Mai Hagiwara, Takahiro Mitsueda, Masaru Matsui, Kazuyuki Nagatsuka, Hidenao Fukuyama, Masafumi Ihara
  • Organizer: The 6th Congress of The International Society for Vascular Behavioral and Cognitive Disorders
  • Place of Presentation: Tronto, Canada
• [Presentation] Montreal Cognitive Assessment Score Correlates with Regional Cerebral Blood Flow in Post-stroke Patients (2013)
  • Author(s): Yuriko Nakaoku, Yoshiki Hase, Naoya Oishi, Tatsuo Manabe, Mai Hagiwara, Takahiro Mitsueda, Masaru Matsui, Kazuyuki Nagatsuka, Hidenao Fukuyama, Masafumi Ihara
  • Organizer: The 6th Korea-Japan Joint Stroke Conference
  • Place of Presentation: Osaka, Japan
• [Presentation] GPGPU for Medical Imaging (2012)
  • Author(s): Naoya Oishi
  • Organizer: Workshop on GPGPU／High-Accurate Computation 2012
  • Place of Presentation: Arima, Japan
  • Invited
• [Presentation] 『PET／SPECTによる中枢系変性疾患の診断』～ 脳血流・糖代謝イメージング ～ (2012)
  • Author(s): 大石直也
  • Organizer: 第28 回BFIC
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 自己組織化マップによる脳糖代謝分布パターン可視化の有用性-MCI患者での検討- (2012)
  • Author(s): 大石直也、石津浩一、並木千尋、福山秀直
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 自己組織化マップに基づくMCI患者の脳糖代謝分布パターンの分類 (2012)
  • Author(s): 大石直也、石津浩一、並木千尋、福山秀直
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: 筑波
• [Book] 認知症と画像診断（総論）．脳とこころのプライマリケア２知能の衰え (2013)
  • Author(s): 大石直也、福山秀直
  • Publisher: シナジー
• [Book] Movement Disordersの画像所見．アクチュアル脳・神経疾患の臨床・パーキンソン病と運動異常 (2013)
  • Author(s): 大石直也、福山秀直
  • Publisher: 中山書店