Development of dose evaluation and treatment planning system of intensity modulated radiation therapy considering dose uncertainties

• Project/Area Number: 24791297
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Niigata University
• Principal Investigator: UTSUNOMIYA Satoru 新潟大学, 医歯(薬)学総合研究科, 助教 (50570868)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 強度変調放射線治療 / 不確かさ / 放射線治療計画 / multi-leaf collimator / 医学物理学 / 感度解析 / マルチリーフコリメータ

Outline of Final Research Achievements

Dose uncertainties in intensity modulated radiation therapy (IMRT) were analyzed qualitatively and quantitatively to create a numerical model to describe those dose uncertainties. We developed a method of creating a robust treatment plan against dose uncertainties due to patient setup error, and a method of quantifying and visualizing dose uncertainties due to error in multi-leaf collimator (MLC) modeling parameters appeared in commissioning of treatment planning system in dose distributions. Based on our developed method, a stable delivery of IMRT and maintaining its accuracy may be feasible even if there are some dose uncertainties which potentially affect to dose delivery accuracy of IMRT.

Research Products

• [Journal Article] 強度変調放射線治療における線量検証の標準化に向けた調査研究 (2015)
  • Author(s): 中村光宏、伊良皆拓、高宮大義、小野智博、秋元麻未、椋本宜学、石原佳知、宇都宮悟、椎木健裕、宮部結城、佐藤清香、門前一
  • Journal Title: 医学物理 Volume: 34 Pages: 208-217
  • NAID: 130005114863
  • Peer Reviewed
• [Journal Article] Superiority of a soft tissue-based setup using cone-beam computed tomography over a bony structure-based setup in intensity-modulated radiotherapy for prostate cancer (2015)
  • Author(s): Hiraku Sato, Eisuke Abe, Satoru Utsunomiya, Motoki Kaidu, Nobuko Yamana, Kensuke Tanaka, Atsushi Ohta, Mika Obinata, Junyang Liu, Gen Kawaguchi, Katsuya Maruyama, Fumio Ayukawa, and Hidefumi Aoyama
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: to be determined
  • Peer Reviewed
• [Journal Article] IMRT治療計画：最適化における様々な工夫 (2014)
  • Author(s): 宇都宮悟
  • Journal Title: 臨床放射線 Volume: Vol.59 No.1 Pages: 227-230
• [Journal Article] A feasibility study on reduction of the entrance-surface dose to neonates by use of a new digital mobile X-ray system (2013)
  • Author(s): Utsunomiya S, Monzen H, Akimoto M, Mukumoto N, Ishihara Y, Shiinoki T, Nakamura M, Miyabe Y, Sato S, Matsuo S, Hiraoka M.
  • Journal Title: Radiol Phys Technol. Volume: 6 Issue: 1 Pages: 157-61
  • DOI: 10.1007/s12194-012-0182-1
  • NAID: 120005241786
  • Peer Reviewed
• [Presentation] A Sensitivity Analysis for Evaluating Dosimetric Impact of MLC Modeling Parameter Accuracy On IMRT Treatment Plans (2014)
  • Author(s): Satoru Utsunomiya
  • Organizer: AAPM 56th Annual Meeting & Exhibition
  • Place of Presentation: Austin, Texas, USA
  • Year and Date: 2014-07-20 – 2014-07-24
• [Presentation] Dosimetric impact of MLC parameters on IMRT treatment plans (2014)
  • Author(s): Naoki Shibuya
  • Organizer: 第107回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 感度解析を用いた前立腺IMRT治療プランの頑強性評価法とその臨床応用
  • Author(s): 宇都宮悟
  • Organizer: 第128回日本医学放射線学会 北日本地方会
  • Place of Presentation: 新潟市
• [Presentation] オーバーラップ体積比率を基にした予測関数による前立腺IMRT治療計画の簡便化
  • Author(s): 宇都宮悟
  • Organizer: 第27回日本高精度放射線外部照射研究会
  • Place of Presentation: 東京都
• [Presentation] 感度解析を用いたIMRT治療プランの頑強性評価法の開発
  • Author(s): 宇都宮悟
  • Organizer: 第103回日本医学物理学会学術大会
  • Place of Presentation: 横浜市
• [Presentation] 感度解析を用いた前立腺IMRT 治療プランの頑強性評価法とその臨床応用
  • Author(s): 宇都宮悟
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京都