A development of Tumor imaging by I-123 Lactsome using small animal SPECT/CT
Project/Area Number |
24791298
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kyoto University |
Principal Investigator |
KURIHARA Kensuke 京都大学, 医学(系)研究科(研究院), 助教 (90531997)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ナノキャリア / ミセル / SPECT-CT / EPR効果 / 腫瘍イメージング / ABC現象 / 転移モデル / 核医学 / SPECT |
Research Abstract |
We aimed at a development of the nanocarrier called Lactsome who is able to diagnose carcinoma. The study of small animal SPECT imaging was performed by using the Lactsome labeled by I-123 or In-111. We repeated improvement of Lactsome, with establishing of various labeled Lactsome and obtaining fluorescent imaging by ICG labeled Lactsome, and performing the biodistribution. As a result, we finally obtained excellent small animal SPECT imaging by using the Lactsome which is called S50-A3B type and labeled by In-111-DOTA. However, there is left many tasks, such as reduction the accumulation to liver and spleen, the suppression of an ABC phenomenon completely, and so on.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.2013
Author(s)
F.Yamamoto, R.Yamahara, A.Makino, K.Kurihara, H.Tsukada, E.Hara, I.Hara, S.Kizaka-Kondoh, Y.Ohkubo, E.Ozeki, S.Kimura
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Journal Title
Nucl. Med. Biol.
Volume: 40
Issue: 3
Pages: 387-394
DOI
Related Report
Peer Reviewed
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[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013
Author(s)
Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E. and Kimura, S.
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Journal Title
Biochem. Biophys. Acta-General Sub.
Volume: 1830
Issue: 8
Pages: 4046-4052
DOI
Related Report
Peer Reviewed
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