| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We developed a model which predicts prognosis before treatment by analyzing correlations between gene expressions of patient blood sample and prognostic data. Gene expressions were obtained by DNA microarray analysis of samples from 51 patients and 5 healthy volunteers, then Principal Component Scores (PCSs) of gene expressions were calculated using Principal Component Analysis. Correlations between prognostic data after carbon ion therapy and PCSs were tested using Spearman's rank correlation coefficient and developed a relationship between gene expressions and prognosis by a part of patient data. After that, we evaluated the model by the rest of patient data and confirmed its usefulness. If we can use this model in clinical practice, it will lead to not only improvement of treatment results but also effective use of carbon ion facilities.
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