| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We aimed to develop novel 68Ga labeled tumor imaging agents which can be produced without cyclotron. We have designed, synthesized and evaluated 68Ga labeled agents targeting folate receptor (FR), which can be internalized by cell trapping. We synthesized a FR agonist based 67Ga-NOTA-NCS-FL and an antagonist based 67Ga-NOTA-NCS-TP. In the saturation binding experiments and in vitro uptake experiments, 67Ga-NOTA-NCS-TP showed higher binding affinity and uptake efficiency than those of 67Ga-NOTA-NCS-FL. Accordingly, 67/68Ga-NOTA-NCS-TP can be a prospective tumor imaging agent targeting FR.
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