Development of novel 68Ga labeled tumor imaging agents based on cell trapping mechanism.
| Project/Area Number |
24791316
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUCHIGAMI Takeshi 長崎大学, 医歯学総合研究科(薬学系), 准教授 (30432206)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PET / 68Ga / ジェネレータ / 腫瘍 / 葉酸受容体 / がん / イメージング |
|---|
| Outline of Final Research Achievements |
We aimed to develop novel 68Ga labeled tumor imaging agents which can be produced without cyclotron. We have designed, synthesized and evaluated 68Ga labeled agents targeting folate receptor (FR), which can be internalized by cell trapping. We synthesized a FR agonist based 67Ga-NOTA-NCS-FL and an antagonist based 67Ga-NOTA-NCS-TP. In the saturation binding experiments and in vitro uptake experiments, 67Ga-NOTA-NCS-TP showed higher binding affinity and uptake efficiency than those of 67Ga-NOTA-NCS-FL. Accordingly, 67/68Ga-NOTA-NCS-TP can be a prospective tumor imaging agent targeting FR.
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Report
(4 results)
Research Products
(58 results)
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[Presentation] プリオン病診断薬としての 125 I 標識ベンゾフラン誘導体の合成と評価2015
Author(s)
川崎 仁央, 小山 隆介, 淵上 剛志, 中垣 岳大, 佐野 和憲, 新 竜一郎, 吉田 さくら, 原武 衛, 小野 正博, 西田 教行, 中山 守雄
Organizer
日本薬学会第135年会
Place of Presentation
神戸学院大学（神戸市）
Year and Date
2015-03-25 – 2015-03-28
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[Presentation] 魚介類中セレン含有物質の分析2014
Author(s)
吉田さくら，古賀香織，原武衛，淵上剛志，中山守雄
Organizer
第25回日本微量元素学会
Place of Presentation
岡山大学（岡山市）
Year and Date
2014-07-03 – 2014-07-04
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[Presentation] Synthesis and evaluation of radioiodinated flavonoid-related compounds as SPECT probes for imaging cerebral prion deposits.2013
Author(s)
T. Fuchigami, Y. Yamashita, A. Ogawa, M. Haratake, R. Atarashi, K. Sano, T. Nakagaki, K. Ubagai, M. Ono, N. Nishida, M. Nakayama
Organizer
Asian Pacific Prion Symposium 2013
Place of Presentation
長崎県 佐世保市 ハウステンボス
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