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Fluids infused radiofrequency ablation for ground glass nodules in lung; basic and clinical research

Research Project

Project/Area Number 24791326
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MIURA Hiroshi  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (20607593)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsラジオ波焼灼療法 / 肺スリガラス結節 / 媒体注入 / 肺ラジオ波焼灼療法
Outline of Final Research Achievements

To access the feasibility of fluids infused radiofrequency ablation (RFA) for pulmonary ground-glass nodules, accumulation and diffusion of fluids in the lung was assessed in lipiodol marking for pulmonary nodules before video-assisted thracoscopic surgery. Lipiodol (0.2ml) was injected with a 21-gauge needle. Size of lipiodol spot obtained was 8.9 mm. Lipiodol was distributed into around structures, however nodular spots were obtained in most cases. Using this technique, RFA with various types of fluids infused was performed on swine with normal lungs. Used fluids were saline, lipiodol and hyaluronic acid. The amount of each fluid was 0.3 ml, respectively. In hyaluronic acid group, coagulation necrosis volume was larger than other groups and hyaluronic acid remained localized. Therefore, hyaluronic acid could be a useful fluid for this method.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013

All Presentation (8 results)

  • [Presentation] CT-guided Lipiodol Marking before Video-Assisted Thoracoscopic Surgery for Small Pulmonary Lesions: Investigation of Pneumothorax and Pulmonary Hemorrhage2014

    • Author(s)
      Miura, H. Yamagami, T. Takezawa, K. Terayama, K. Tanaka, O. Ichijo, Y. Asai, S. Hayashi, N. Shimomura, M. Kato, D. Shimada, J. Takeuchi, Y.
    • Organizer
      The 50th Autumn Assembly of the Japan Radiological Society
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 正常豚肺における媒体注入ラジオ波焼灼療法:microbubble発生の検討2014

    • Author(s)
      田中匡, 三浦寛司, 田中治, 永野仁美, 牛嶋陽, 加藤武晴, 小谷知也, 吉松梨香, 山上卓士
    • Organizer
      第43回日本IVR学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Various types of fluids infused radiofrequency ablation in lung: investigation using a swine model2014

    • Author(s)
      Nagano H, Miura H, Takeuchi Y, Terayama K, Tanaka O, Yoshimatsu R, Ichijo Y, Tanaka T, Yamagami T
    • Organizer
      ECR2014
    • Place of Presentation
      ウイーン
    • Related Report
      2013 Research-status Report
  • [Presentation] Incidence and Risk Factors of Pneumothorax and Pulmonary Hemorrhage after CT-guided Lipiodol Marking before Video-assisted Thoracoscopic Surgery for Small Pulmonary Lesions2014

    • Author(s)
      Takezawa K, Miura H, Terayama K, Tanaka O, Yoshimatsu R, Kato D, Shimada J, Yamagami T
    • Organizer
      ECR2014
    • Place of Presentation
      ウイーン
    • Related Report
      2013 Research-status Report
  • [Presentation] 正常豚肺における媒体注入下ラジオ波焼灼療法の検討2013

    • Author(s)
      三浦寛司、山上卓司、寺山耕司、田中治、吉松梨香、一条祐輔、加藤大志朗、島田順一
    • Organizer
      第49回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] Patterns of accumulation of lipiodol in computed tomography-guided lipiodol marking before video-assisted thoracoscopic sugery of small pulmonary nodules.2013

    • Author(s)
      Miura H, Yamagami T, Terayama K, Tanaka O, Yoshimatsu R, Ichijo Y, Kato D, Shimada J
    • Organizer
      Cardiovascular and Interventional Radiological Society of Europe 2013
    • Place of Presentation
      バルセロナ
    • Related Report
      2013 Research-status Report
  • [Presentation] 肺内小病変に対する術前CTガイド下リピオドールマーキングにおけるリピオドールの貯留パターンの検討2013

    • Author(s)
      三浦寛司、山上卓司、寺山耕司、田中治、吉松梨香、一条祐輔、加藤大志朗、島田順一
    • Organizer
      第42回日本IVR学会総会
    • Place of Presentation
      軽井沢
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Patterns of accumulation of lipiodol in computed tomography - guided lipiodol marking before video - assisted thoracoscopic surgery of small pulmonary nodules2013

    • Author(s)
      三浦寛司
    • Organizer
      CIRSE 2013
    • Place of Presentation
      バルセロナ
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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