Development of tumor control probability model based on probability theory
| Project/Area Number |
24791334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 前立腺癌 / 腫瘍制御モデル / 低線量率 / 高線量率 / 小線源治療 / アルファベータ比 / 定位放射線治療 / 国際研究者交流 / 多国籍 |
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| Outline of Final Research Achievements |
Retrospective analysis of 305 prostate cancer patients treated by low-dose-rate brachytherapy with 66 months follow-up was published in paper. In addition retrospective analysis of 178 patients teated by high-dose rate brachytherapy was also published in another paper. Although we tried to find differences between these two dose-rate brachytherapy and to make a tumor control probability model (TCP) based on these data, there was no significant differences as these treatments had very low recurrence rates and it was difficult to make a reasonable TCP model.
We also tried to take a biological approach in addition to above mentioned clinical approach. Although we started to examine the relationship between radiation dose and DNA double-strand brake, there was no time to complete this examination untile the end of study period.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer.2015
Author(s)
Ishiyama H, Satoh T, Sekiguchi A, Tabata K, Komori S, Tsumura H, Kawakami S, Soda I, Takenaka K, Iwamura M, Hayakawa K
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Journal Title
J Contemp Brachytherapy
Volume: 7
Pages: 3-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Catheter displacement prior to the delivery of high-dose-rate brachytherapy in the treatment of prostate cancer patients2014
Author(s)
Kawakami, S., Ishiyama, H., Terazaki, T., Soda, I., Satoh, T., Kitano, M., Kurosaka, S., Sekiguchi, A., Komori, S., Iwamura, M., Hayakawa, K.
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Journal Title
J Contemp Brachytherapy
Volume: 6
Pages: 161-6
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A prospective quasi-randomized comparison of intraoperatively built custom-linked seeds versus loose seeds for prostate brachytherapy2014
Author(s)
Ishiyama, H., Satoh, T., Kawakami, S., Tsumura, H., Komori, S., Tabata, K. I., Sekiguchi, A., Takahashi, R., Soda, I., Takenaka, K., Iwamura, M., Hayakawa, K.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 90
Issue: 1
Pages: 134-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term hormonal therapy for high-risk and very high-risk prostate cancer: outcomes after 5-year follow-up2014
Author(s)
Ishiyama H, Satoh T, Kitano M, Tabata KI, Komori S, Ikeda M, Soda I, Kurosaka S, Sekiguchi A, Kimura M, Kawakami S, Iwamura M, Hayakawa K
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Journal Title
Journal of Radiation Research
Volume: 印刷中
Related Report
Peer Reviewed
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