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Development of tumor control probability model based on probability theory

Research Project

Project/Area Number 24791334
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKitasato University

Principal Investigator

ISHIYAMA Hiromichi  北里大学, 医学部, 講師 (60343076)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords前立腺癌 / 腫瘍制御モデル / 低線量率 / 高線量率 / 小線源治療 / アルファベータ比 / 定位放射線治療 / 国際研究者交流 / 多国籍
Outline of Final Research Achievements

Retrospective analysis of 305 prostate cancer patients treated by low-dose-rate brachytherapy with 66 months follow-up was published in paper. In addition retrospective analysis of 178 patients teated by high-dose rate brachytherapy was also published in another paper. Although we tried to find differences between these two dose-rate brachytherapy and to make a tumor control probability model (TCP) based on these data, there was no significant differences as these treatments had very low recurrence rates and it was difficult to make a reasonable TCP model.
We also tried to take a biological approach in addition to above mentioned clinical approach. Although we started to examine the relationship between radiation dose and DNA double-strand brake, there was no time to complete this examination untile the end of study period.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer.2015

    • Author(s)
      Ishiyama H, Satoh T, Sekiguchi A, Tabata K, Komori S, Tsumura H, Kawakami S, Soda I, Takenaka K, Iwamura M, Hayakawa K
    • Journal Title

      J Contemp Brachytherapy

      Volume: 7 Pages: 3-9

    • DOI

      10.5114/jcb.2015.48603

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catheter displacement prior to the delivery of high-dose-rate brachytherapy in the treatment of prostate cancer patients2014

    • Author(s)
      Kawakami, S., Ishiyama, H., Terazaki, T., Soda, I., Satoh, T., Kitano, M., Kurosaka, S., Sekiguchi, A., Komori, S., Iwamura, M., Hayakawa, K.
    • Journal Title

      J Contemp Brachytherapy

      Volume: 6 Pages: 161-6

    • DOI

      10.5114/jcb.2014.43619

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A prospective quasi-randomized comparison of intraoperatively built custom-linked seeds versus loose seeds for prostate brachytherapy2014

    • Author(s)
      Ishiyama, H., Satoh, T., Kawakami, S., Tsumura, H., Komori, S., Tabata, K. I., Sekiguchi, A., Takahashi, R., Soda, I., Takenaka, K., Iwamura, M., Hayakawa, K.
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 90 Issue: 1 Pages: 134-9

    • DOI

      10.1016/j.ijrobp.2014.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term hormonal therapy for high-risk and very high-risk prostate cancer: outcomes after 5-year follow-up2014

    • Author(s)
      Ishiyama H, Satoh T, Kitano M, Tabata KI, Komori S, Ikeda M, Soda I, Kurosaka S, Sekiguchi A, Kimura M, Kawakami S, Iwamura M, Hayakawa K
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 125Iodine monotherapy for Japanese men with low- and intermediate-risk prostate cancer: outcomes after 5 years of follow-up2014

    • Author(s)
      Sekiguchi A, Ishiyama H, Satoh T, Tabata K, Komori S, Tsumura H, Kawakami S, Soda I, Iwamura M, Hayakawa K
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Issue: 2 Pages: 328-333

    • DOI

      10.1093/jrr/rrt113

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 限局性前立腺癌に対する125I密封小線源永久挿入療法306例の治療成績

    • Author(s)
      111. 関口茜衣、石山博條、佐藤威文、小森承子、早田格、川上正悟、早川和重
    • Organizer
      日本放射線腫瘍学会第25回学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 前立腺癌に対する高線量率組織内照射におけるアプリケーター移動に関する検討

    • Author(s)
      112. 川上 正悟、石山 博條、寺崎 剛史、北野 雅史、早田 格、佐藤 威文、小森 承子、関口 茜衣、早川 和重
    • Organizer
      日本放射線腫瘍学会第25回学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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