| Project/Area Number |
24791341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
MOTEGI Atsushi 独立行政法人国立がん研究センター, 東病院, 医員 (10433997)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 放射線感受性 / 中咽頭癌 / がん幹細胞マーカー / CD44 / p16 / HPV / 放射線治療 / 放射線生物学 / がん幹細胞 / 免疫組織化学 |
|---|
| Outline of Final Research Achievements |
To elucidate the correlation between cancer-stem-cell marker expression and tumor radiosensitivity, immunohistochemical analysis in head and neck cancer was performed. Expression of cancer-stem-cell marker CD44 and p16, the surrogate marker of HPV infection, in oropharyngeal cancer were investigated retrospectively. The impact of protein expressions on treatment outcomes were also investigated. The loco-regional control rates of the patient with CD44 expression was significantly worse than those without CD44 expression. And moreover, the combined analysis of CD44 and p16 showed that patients with CD44 negative and p16 positive expression had the best treatment outcomes, and those with CD44 positive and p16 negative expression had the worst treatment outcomes. This result might indicate that cause of tumorigenesis can affect cancer-stem-cell marker expression in oropharyngeal cancer.
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