Intra-arterial infusion of thrombin: animal experiments
Project/Area Number |
24791344
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kansai Medical University |
Principal Investigator |
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Research Collaborator |
INOUE Michito
KOMEMUSHI Sadao
KARIYA Shuji
TANIGAWA Noboru
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | IVR / DDS / 低侵襲治療 / Interventional Radiology / 放射線医学 / Oncology / 化学療法 / インターベンショナルラジオロジー / カテーテル治療 / トロンビン / ドラッグデリバリーシステム / 血管内治療 / インターベンショナルラジオロジー(IVR) / ドラッグデリバリーシステム(DDS) |
Outline of Final Research Achievements |
The platinum concentrations in plasma in 5 and 10 minutes after administration were 0.59±0.28μg/ml and 0.70±0.078μg/ml for the thrombin group, respectively, and 2.7±1.2μg/ml and 2.2±0.58μg/ml for the control group, respectively. At both 5 and 10 min after infusion, the platinum concentrations in plasma for the thrombin group were significant lower than that for the control group. The platinum concentration in tumor tissue was 4.1±1.8 μg/wet・g for the thrombin group and 1.0±1.2μg/wet・g for the control group. The platinum concentration in tumor tissue for the thrombin group was significantly higher than that for the control group. The present results suggest that transarterial infusion with thrombin may have a number of pharmacological advantages.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Feasibility and Safety of Dexmedetomidine Sedation in Transarterial Embolization for Hepatocellular Carcinoma with Hepatitis C-Related Cirrhosis2015
Author(s)
Komemushi A, Suzuki S, Sano A, Kariya S, Nakatani M, Yoshida RY, Kono Y, Ikeda K, Utsunomiya K, Harima Y, Tanigawa N.
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Journal Title
Gan To Kagaku Ryoho.
Volume: 42
Pages: 1077-1079
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of Tc-99m GSA scintigraphy and CT volumetry for evaluation in portal vein embolization.2014
Author(s)
Kono Y, Kariya S, Komemushi A, Nakatani M, Yoshida RY, Suzuki S, Ha-Kawa SK, Utsunomiya K, Ueno Y, Satoi S, Kaibori M, Kon M, Tanigawa N.
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Journal Title
Minim Invasive Ther Allied Technol.
Volume: 23
Issue: 4
Pages: 241-246
DOI
Related Report
Peer Reviewed
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[Journal Article] Radiation dose of nurses during IR procedures: a controlled trial evaluating operator alerts before nursing tasks.2014
Author(s)
Komemushi A, Suzuki S, Sano A, Kanno S, Kariya S, Nakatani M, Yoshida R, Kono Y, Ikeda K, Utsunomiya K, Harima Y, Komemushi S, Tanigawa N.
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Journal Title
J Vasc Interv Radiol.
Volume: 25
Issue: 8
Pages: 1195-1199
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intra-arterial infusion of thrombin: animal experiments.2014
Author(s)
Komemushi A, Kariya S, Nakatani M, Yoshida R, Kono Y, Suzuki S, Kanno S, Ikeda K, Utsunomiya K, Harima Y, Oyamada K, Kamiyoshi T, Miyake T, Sato R, Inoue M, Tanigawa N.
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Journal Title
Minim Invasive Ther Allied Technol
Volume: 23
Issue: 1
Pages: 52-54
DOI
Related Report
Peer Reviewed
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[Presentation] 外傷出血2015
Author(s)
米虫 敦
Organizer
第13回日本IVR学会夏季学術セミナー
Place of Presentation
神奈川県、テルモメディカルプラネクス
Year and Date
2015-08-08
Related Report
Invited
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[Presentation] Evaluation of an aspiration-type semiautomatic cutting biopsy needl2015
Author(s)
Atsushi Komemushi , Makiko Miyamoto , Satoshi Suzuki, Akira Sano, Shohei Kanno, Shuji Kariya, Miyuki Nakatani, Rie Yoshida, Yumiko Kono, Takaya Tsuno, Yuko Kikukawa, Noriko Takada, Tomomi Tojo, Kazuko Aoki, Koshi Ikeda, Keita Utsunomiya, Yoko Harima, Hanako Matsuoka, Sadao Komemushi, Noboru Tanigawa
Organizer
SIR 40th Annual Scientific Meeting
Place of Presentation
World Convention Center, Atlanta, GA, U.S.A.
Year and Date
2015-03-28 – 2015-04-06
Related Report
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[Presentation] 教育講演36:椎体形成術2014
Author(s)
米虫 敦
Organizer
第73回日本医学放射線学会総会
Place of Presentation
神奈川県、パシフィコ横浜
Year and Date
2014-04-10 – 2014-04-13
Related Report
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[Presentation] Intra-arterial infusion of thrombin: animal experiments2013
Author(s)
Atsushi Komemushi, Noboru Tanigawa, Shuji Kariya, Miyuki Nakatani, Rie Yoshida, Satoshi Suzuki, Koshi Ikeda, Keita Utsunomiya, Shohei Kanno, Yoko Harima, Satoshi Sawada, Michoto Inoue, Kazuhisa Oyamada, Kamiyoshi Tsuyoshi, Tsuyoshi Miyake, Ryo Sato
Organizer
American Roentegn Ray Society Annual Meeting 2013
Place of Presentation
Washington, D.C., U.S.A.
Related Report
Invited
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