| Project/Area Number |
24791352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KIMURA Yasuyuki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (20423171)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 代謝型グルタミン酸受容体サブタイプ 5 / ポジトロンエミッショントモグラフィー / reproducibility / 代謝型グルタミン酸受容体サブタイプ5 / mGluR5 / PET / ドーパミントランスポーター |
|---|
| Outline of Final Research Achievements |
To establish a method to quantify density of metabotropic glutamate receptor subtype 5 in human brain, which is related to the interaction between glutamatergic and dopaminergic neurons, we evaluated a new PET ligand, 11C-(E)ABP688, in healthy volunteers as a test-retest study in a same day. As results, distribution volume of 11C-(E)ABP688 was well estimated, and its regional distribution was consistent with the know distribution of the receptor. However, its reproducibility was poor that 30% decrease in the distribution volume was observed in the afternoon compared to in the morning.
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