The effect of fractionated radiotherapy for tumor metastatic abilities
| Project/Area Number |
24791358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba (2014)
National Institute of Radiological Sciences (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 不均等分割 / 初回高線量 / 粒子線治療 / 細胞死 / 転移能 / 浸潤能 / 不均等分割照射 / 高LET / 細胞致死 / スフェロイド / 転移 / 分割照射 / 遊走能 |
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| Outline of Final Research Achievements |
In clinic, even fractionated radiotherapy is being used for tumor therapy, however it was reposted that low dose irradiation with low LET enhance the lung metastasis of mice bearing tumor and the invasion ability of cancer cells. Is even fractionated irradiation really best from the angle of the antimetastatic?
In this study, at first we tried to examine the effect of even fractionated irradiation of X-rays and carbon-ion (C-ions) beams to both cytotoxicity and anti-invasion ability, and the correlation between the effects and the fraction number and/or fraction size were clarified. Next, we examined the effects of un-even fractionated irradiation of X-rays and C-ions for to cytotoxicity and anti-metastatic effects using single layer cultured cells and multicellular spheroids techniques. As a result, it is suggested that the uneven fractionated radiotherapy with high dose at the first fraction is most useful to both induce the cell death and suppress the tumor invasiveness.
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Report
(4 results)
Research Products
(28 results)
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[Presentation] The effect of heavy-ion beam to metastatic abilities and survival of tumor cells cultured in cyclic hypoxia condition2014
Author(s)
Yoshitaka Matsumoto, Kei Yamashita, Huizu Li, Yumiko Kaneko, Lue Sun, Takeshi Moritake, Akiko Uzawa, Ryoichi Hirayama, Koichi Ando, Shinichiro Masunaga, Toshiyuki Shirai, Yoshiya Furusawa and Hideyuki Sakurai
Organizer
41st Annual Meeting of the European Radiation Research Society
Place of Presentation
Alder Paradise Mare (Rhodes, Greece)
Year and Date
2014-10-14 – 2014-10-19
Related Report
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[Presentation] Dose and LET Dependency of Bystander-Induced Micronucleation in Normal Human Fibroblasts2013
Author(s)
Yoshitaka Matsumoto, Nobuyuki Hamada, Mizuho Aoko-Nakano, Seiichi Wada, Tomoo Funayama, Tetsuya Sakashita, Noriko Usami, Takehiko Kakizaki, Katsumi Kobayashi, Yasuhiko Kobayashi, Yoshiya Furusawa
Organizer
16th International Symposium of Microdosimetry
Place of Presentation
Treviso, Italy
Related Report
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