| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In clinic, even fractionated radiotherapy is being used for tumor therapy, however it was reposted that low dose irradiation with low LET enhance the lung metastasis of mice bearing tumor and the invasion ability of cancer cells. Is even fractionated irradiation really best from the angle of the antimetastatic?
In this study, at first we tried to examine the effect of even fractionated irradiation of X-rays and carbon-ion (C-ions) beams to both cytotoxicity and anti-invasion ability, and the correlation between the effects and the fraction number and/or fraction size were clarified. Next, we examined the effects of un-even fractionated irradiation of X-rays and C-ions for to cytotoxicity and anti-metastatic effects using single layer cultured cells and multicellular spheroids techniques. As a result, it is suggested that the uneven fractionated radiotherapy with high dose at the first fraction is most useful to both induce the cell death and suppress the tumor invasiveness.
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