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Optimization of number and direction of beams in intensity modulated proton therapy

Research Project

Project/Area Number 24791359
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

INANIWA Taku  独立行政法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (10446536)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords粒子線治療 / 放射線治療 / 陽子線治療 / 多門照射
Research Abstract

Since tumor is usually located deep inside the body, it is inevitable that normal tissues surrounding the tumor undergo unfavorable irradiation. To reduce such irradiation, several techniques have been adopted in charged particle therapy, such as (1) multi-port irradiation, (2) Selection of beam direction avoiding organ at risk and (3) fractionated irradiation. With regard to (1) and (2), an optimum combination of beam directions differs for each treatment and patient. The purpose of this study is to look for a fast and simplified algorithm with which a combination of irradiation directions can be optimized. It turned out that (1) to select the direction oppose to organ at risk and (2) to separate two irradiation directions as far as possible are effective to reduce irradiation normal tissue. An optimal choice of irradiation direction can be obtained in short computation time.
Part of this study has been summarized in a manuscript, and will be submitted to an European journal.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (14 results) (of which Invited: 9 results)

  • [Journal Article] 放医研における粒子線スキャニング法の開発2013

    • Author(s)
      稲庭拓
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 32巻 Pages: 74-80

    • NAID

      130003397832

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 重粒子線治療の最先端技術2014

    • Author(s)
      稲庭拓
    • Organizer
      第2回医療放射線技術研究会
    • Place of Presentation
      東京, 日本
    • Year and Date
      2014-03-16
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 重粒子線治療の最先端技術2014

    • Author(s)
      稲庭拓
    • Organizer
      第2回医療放射線技術研究会 (応用物理学会主催)
    • Place of Presentation
      東京、日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Dose-delivery time structure on biological effectiveness in charged particle therapy2014

    • Author(s)
      Taku Inaniwa
    • Organizer
      First Author’s Affiliation : Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
    • Place of Presentation
      Hokkaido, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Rationale of charged particle therapy2013

    • Author(s)
      Taku Inaniwa
    • Organizer
      JSPS International School
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2013-09-17
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 粒子線スキャニング照射法とその可能性2013

    • Author(s)
      稲庭拓
    • Organizer
      第105回日本医学物理学会学術大会
    • Place of Presentation
      神奈川, 日本
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 強度変調混合イオン照射法の提案2013

    • Author(s)
      稲庭拓, 兼松伸幸, 古川卓司, 森慎一郎, 白井敏之
    • Organizer
      第105回日本医学物理学会学術大会
    • Place of Presentation
      神奈川, 日本
    • Related Report
      2013 Final Research Report
  • [Presentation] 強度変調複合イオン照射法の提案 Proposal of Intensity Modulated Composite Ion Therapy (IMCIT)2013

    • Author(s)
      稲庭拓、古川卓司、兼松伸幸、森慎一郎、白井敏之
    • Organizer
      第105会日本医学物理学会学術大会
    • Place of Presentation
      神奈川、日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 粒子線スキャニング照射法とその可能性2013

    • Author(s)
      稲庭拓
    • Organizer
      第105会日本医学物理学会学術大会 教育講演
    • Place of Presentation
      神奈川、日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Rationale of charged particle radiotherapy2013

    • Author(s)
      Taku Inaniwa
    • Organizer
      JSPS International School
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Radiotherapy with scanned-ion beams2012

    • Author(s)
      稲庭拓
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      茨城, 日本
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 重ね合わせ照射のためのRobust 最適化演算法2012

    • Author(s)
      稲庭拓, 兼松伸幸, 古川卓司, 森慎一郎, 白井敏之, 野田耕司
    • Organizer
      第103回日本医学物理学会学術大会
    • Place of Presentation
      神奈川, 日本
    • Related Report
      2013 Final Research Report
  • [Presentation] A microdosimetric kinetic model for RBE prediction in carbon ion radiotherapy2012

    • Author(s)
      Taku Inaniwa
    • Organizer
      Mini Micro Nani Dosimetry 2012
    • Place of Presentation
      Wollongong, Australia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 重ね合わせ照射のためのRobust最適化演算法2012

    • Author(s)
      稲庭拓、兼松伸幸、古川卓司、森慎一郎、白井俊之、野田耕司
    • Organizer
      第103回日本医学物理学会学術大会
    • Place of Presentation
      神奈川、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Radiotherapy with scanned-ion beams2012

    • Author(s)
      稲庭拓
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      筑波、日本
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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