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Study on early diagnosis and cost-effectiveness to the dementia patients using amyloid imaging

Research Project

Project/Area Number 24791363
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2014)
独立行政法人国立精神・神経医療研究センター (2012)

Principal Investigator

ITO KIMITERU  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40602074)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords認知症 / PET / アミロイド / アミロイドイメージング / SPECT / MRI / 該当なし
Outline of Final Research Achievements

The aim of this study was to evaluate the impact of amyloid positron emission tomography (PET) to diagnose elderly patients with dementia in daily practice. Amyloid PET showed positive findings in forty-eight out of eighty-five patients with cognitive disorders who were diagnosed by the clinical criteria of the National Institute on Aging-Alzheimer’s Association (NIA-AA). Our result suggested amyloid PET had clinical impacts on patients with Alzheimer`s disease and mild cognitive impairments who were diagnosed based on the clinical criteria alone. The diagnosis of dementia using amyloid PET may be helpful to change the pharmacological regimen of dementia patients. Our results suggest that amyloid PET contribute medical care economy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Concordance between 99m Tc-ECD SPECT and 18 F-FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA-AA criteria.2014

    • Author(s)
      3.Ito K, Shimano Y, Imabayashi E, Nakata Y, Omachi Y, Sato N, Arima K, Matsuda H.
    • Journal Title

      Int J Geriatr Psychiatry. Int J Geriatr Psychiatry.

      Volume: 29 Pages: 1079-1086

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Concordance between 99m Tc-ECD SPECT and 18 F-FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA-AA criteria2014

    • Author(s)
      Ito K, Shimano Y, Imabayashi E, Nakata Y, Omachi Y, Sato N, Arima K, Matsuda H.
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 29 Issue: 10 Pages: 1079-1086

    • DOI

      10.1002/gps.4102

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Massive accumulation of 11C-Pittsburg compound B in the occipital lobes of a patient with early-onset dementia accompanied by muscle weakness and hypertonicity2013

    • Author(s)
      Ito K, Sano T, Kamiya K, Nakata Y, Shigemoto Y, Sato N, Oya Y, Matsuda H
    • Journal Title

      Ann Nucl Med

      Volume: 27 Issue: 10 Pages: 935-941

    • DOI

      10.1007/s12149-013-0762-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 超高齢化社会の認知症における画像診断2015

    • Author(s)
      伊藤公輝
    • Organizer
      第74回日本医学放射線学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高齢者における認知症の画像診断2014

    • Author(s)
      伊藤公輝
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 99mTc-ECD SPECTと18F-FDG PETによる集積評価一致率の検討2014

    • Author(s)
      伊藤公輝
    • Organizer
      第12回脳核医学画像解析研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of the Diagnostic Abilities of Two Types of Software for Patients with Amyloid PET Positive Alzheimer Disease : "Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD)" in MRI versus “Specific Volumetric Analysis (SVA)" in Brain Perfusion SPECT.2014

    • Author(s)
      Ito K, Tokumaru A, Sato N, Matsuda H.
    • Organizer
      KSNHNR Annual Meeting & NRF 2014
    • Place of Presentation
      Inchon korea
    • Year and Date
      2014-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 本邦での認知症診療におけるアミロイドイメージングを使用したNIA-AAの診断基準導入の検討2014

    • Author(s)
      伊藤公輝
    • Organizer
      第53回日本核医学学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison with diagnostic abilities of two software in the patients with amyloid PET positive Alzheimer's disease."Vocel based Specific Regional Analysis System for Alzheimer's disease (VSRAD)" in MRI versus "Specific volumetric analysis (SVA)" in brain perfusion SPECT2014

    • Author(s)
      Ito kimiteru
    • Organizer
      KSNHNR Annual Meeting & neuroradiology Forum 2014
    • Place of Presentation
      Inchon Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 99mTc-ECD SPECTと18F-FDG PETの視覚評価を使用した集積一致率に関する検討

    • Author(s)
      伊藤公輝
    • Organizer
      第80回日本核医学学会関東甲信越地方会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 後頭葉に著明なPiB集積を認めた若年性認知症の一例

    • Author(s)
      伊藤公輝
    • Organizer
      第79回日本核医学学会関東甲信越地方会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 後頭葉に著明なPiB集積を認めた若年性認知症の一例

    • Author(s)
      伊藤 公輝
    • Organizer
      関東核医学地方会
    • Place of Presentation
      東京富士フイルム西麻布本社講堂
    • Related Report
      2012 Research-status Report
  • [Book] ここが知りたい 認知症の画像診断 Q&A2013

    • Author(s)
      松田博史、朝田隆、佐藤典子、根本清貴、徳丸阿耶、伊藤公輝
    • Total Pages
      207
    • Publisher
      harunosora
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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