The identification of HLA class II DR associated molecules contributing to Accommodation
| Project/Area Number |
24791371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASAKI Kenta 名古屋大学, 医学(系)研究科(研究院), 寄附講座講師 (10508881)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫順応 / シグナル伝達 / 抗体関連型拒絶反応 / HLA抗体関連型拒絶反応 / 移植 / HLA |
|---|
| Research Abstract |
Expression of HLA-DR on endothelial cells was elicited by IFNg treatment. HLA class I expression was also increased about 4-5 fold. When treated with IFNg, anti-HLA class I and DR antibody binding to endothelial cells did not show any cytoprotective effect against complement-mediated cytotoxicity (CDC) and activated AKT signal, while pre-incubation with anti-A antibody habe resistance to CDC. Anti-HLA class II DR IgG antibody purified from patient sera decreased CD59 expression.
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Report
(3 results)
Research Products
(18 results)
