Instruction of the insulin-producing cell by Direct Reprogramming

• Project/Area Number: 24791374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: IWAGAMI Yoshifumi 大阪大学, 医学部附属病院, 医員 (60597441)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ADSC / MafA / PDX-1 / Ngn3 / Direct Reprogramming / インスリン

Research Abstract

Direct reprogramming by introducing pancreatic transcription factors (MafA, PDX-1, Ngn3) into adipose tissue derived stem cell (ADSC) could not induce insulin-producing cell in vitro and in vivo (limited hepatic transplantation), in my study.