Immunological monitoring after lung transplantation by measurement of serum human leukocyte antigen specific IgM
| Project/Area Number |
24791377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 急性拒絶反応 / 肺移植 / 液性免疫 / 細胞性免疫 / モニタリング / 移植免疫 / 抗HLA抗体価 / IgM / 抗HLA抗体 / 免疫学的活動性 |
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| Outline of Final Research Achievements |
This study aimed to examine that HLA-specific IgM in lung transplant recipient’s sera can be a reasonable marker for immunological activity of acute rejection. As a methodology for HLA-IgM detection, the Flow PRA method was employed and reasonable detectability was confirmed. HLA-IgM value at the time of development of acute rejection was significantly higher than that of immunologically stable condition. Furthermore, the serum HLA-IgM value was unaffected by nonspecific inflammatory response caused by acute stress of common thoracic surgery. This study indicates that monitoring HLA-IgM can contribute to predicting the development of acute lung transplant rejection and determining optimal immunosuppressive management.
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Report
(4 results)
Research Products
(3 results)
