Verification of effectiveness and safeness of hypoxic preconditioning on the functional capacities of human peripheral blood mononuclear cells
| Project/Area Number |
24791378
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 低酸素プレコンディショニング / 末梢血単核球細胞 |
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| Research Abstract |
Hypoxic preconditioned human peripheral blood mononuclear cells (PBMNCs) displayed significantly enhanced functional capacities and increased the resistance to oxidative stress, cell viability, and production of vascular endothelial growth factor. In addition, autologous transplantation of hypoxic preconditioned rabbit PBMNCs significantly induced new vessels and improved limb blood flow in rabbit hindlimb ischemia. Our study demonstrate that hypoxic preconditioning of PBMNCs is an effective way for enhancing angiogenesis in ischemic tissue.
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Report
(3 results)
Research Products
(10 results)
