The effect of sodium zinc dihydrolipoylhistidinate to treat chemotherapy induced alopecia

• Project/Area Number: 24791385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Oita University
• Principal Investigator: NAKAJIMA Kentaro 大分大学, 医学部, 医員 (10625255)
• Research Collaborator: INOMATA Masafumi 大分大学, 医学部, 教授 (60315330) ; KONO Yohei 豊後大野市民病院, 外科 (90572008) ; HIRATSUKA Takahiro 大分大学, 医学部, 病院特任助教 (20600886) ; SUGITA Satoshi 大分医療センター, 外科 (20625470) ; ASO Yuiko 大分大学, 医学部, 研究員 (60635358)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 乳がん / 脱毛 / 腫瘍学 / 乳癌

Outline of Final Research Achievements

Hair loss in the anticancer drug treatment period affects the treatment compliance by lowering the QOL of patients. This is a strategic project which focuses not only basic but also places a view to clinical application. We have showed that novel α-lipoic acid derivatives, DHL-HisZnNa, vitamin E derivative ESeroS-GS, and the ETS-GS inhibited the anti-cancer agents induced alopecia. We revealed these novel antioxidants has anti-tumor effect rather, without attenuating the anti-cancer effect with the anti-cancer agent.

Research Products

• [Journal Article] Anti-Glycation activity of alpha-lipoic acid derivatives and vitamin E derivatives (2014)
  • Author(s): Shimode A, Yagi M, Hagiwara S, Noguchi T, Inomata M, Kitano S, Yonei Y
  • Journal Title: Anti-Aging Medicine Volume: 10(3) Pages: 42-54
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rat (2013)
  • Author(s): Kawano Y, Ohta M, Eguchi H, Iwashita Y, Inomata M, Kitano S
  • Journal Title: J Gastroenterol Hepatol Volume: 28（4） Issue: 4 Pages: 639-644
  • DOI: 10.1111/jgh.12101
  • Peer Reviewed
• [Journal Article] Anti-Glycation Activity of Alpha-Lipoic Acid Derivatives and Vitamin E Derivatives (2013)
  • Author(s): Shimode A, Yagi M, Hagiwara S, Noguchi T, Inomata M, Kitano S, Yonei Y
  • Journal Title: アンチエイジング医学 Volume: 10（3） Pages: 42-54
  • Peer Reviewed
• [Journal Article] Phototherapy with artificial light suppresses dextran sulfate sodium-induced colitis in a mouse model (2013)
  • Author(s): Hiratsuka T, Inomata M, Goto S, Oyama Y, Nakano T, Chen CL, Shiraishi N, Noguchi T, Kitano S
  • Journal Title: J Gastroenterology and Hepatology Volume: 29(4) Issue: 4 Pages: 749-756
  • DOI: 10.1111/jgh.12460
  • Peer Reviewed
• [Journal Article] DHL-TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells (2013)
  • Author(s): Hiratsuka T, Inomata M, Kono Y, Yokoyama S, Shiraishi N, Kitano S.
  • Journal Title: Oncology Report Volume: 29（6） Issue: 6 Pages: 2140-2146
  • DOI: 10.3892/or.2013.2394
  • Peer Reviewed
• [Journal Article] Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model (2013)
  • Author(s): Sugita S, Inomata M, Kono Y, Shiroshita H, Etoh T, Shiraishi N, Kitano S
  • Journal Title: Oncol Lett Volume: 6(5) Pages: 1229-1233
  • Peer Reviewed
• [Journal Article] Biological predictors of survival in stage II colorectal cancer. (2013)
  • Author(s): Ueda Y, Yasuda K, Inomata M, Shiraishi N, Yokoyama K, Kitano S
  • Journal Title: Morecular and Clinical Oncology Volume: in press
  • Peer Reviewed
• [Journal Article] Bolus injection of newly synthesized vitamin E derivative ETS-GS for the treatment of acute severe ulcerative colitis in a mouse model. New vitamin E derivative for acute severe UC. (2013)
  • Author(s): Hiratsuka T, Inomata M, Hagiwara S, Kono Y, Shiraishi N, Noguchi T, Kitano S.
  • Journal Title: Int J colorectal Dis. Volume: 28(3) Issue: 3 Pages: 305-11
  • DOI: 10.1007/s00384-012-1502-y
  • Peer Reviewed
• [Journal Article] A newly synthetic vitamin E derivative, E-Ant-S-GS, attenuates lung injury caused by cecal ligation and puncrure-unduced sepsis in rats (2012)
  • Author(s): Kono Y, Inomata M, Hagiwara S, Shiraishi N, Noguchi T, Kitano S
  • Journal Title: Surgery Volume: 151(3) Issue: 3 Pages: 420-426
  • DOI: 10.1016/j.surg.2011.08.003
  • Peer Reviewed
• [Journal Article] Antiproliferative effects of a new α-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro (2012)
  • Author(s): Kono Y, Inomata M, Hagiwara S, Hiratsuka T, Suzuki K, Koga H, Shiraishi N, Noguchi T, Kitano S
  • Journal Title: Expert Opinion On Therapeutic Targets Volume: 16(S1) Issue: sup1 Pages: S103-S109
  • DOI: 10.1517/14728222.2011.640320
  • Peer Reviewed
• [Presentation] 水溶性αリポ酸誘導体DHL-Tau.Znのラジカル除去能：ESRによる検討 (2014)
  • Author(s): 若山 愛海
  • Organizer: 第5回 癌、炎症と抗酸化研究会
  • Place of Presentation: 別府国際コンベンションセンターB-Con Plaza（大分県別府市山の手町12-1）
  • Year and Date: 2014-11-15
• [Presentation] Therapeutic Potential of α-Lipoic Acid Derivative DHL-HisZn in Allergy (2014)
  • Author(s): Li-Wen Hsu
  • Organizer: 第5回 癌、炎症と抗酸化研究会
  • Place of Presentation: 別府国際コンベンションセンターB-Con Plaza（大分県別府市山の手町12-1）
  • Year and Date: 2014-11-15
• [Presentation] αリポ酸誘導体DHLHZnはラットのオキサリプラチン誘導末梢神経障害を改善する (2013)
  • Author(s): 杉田諭、二日市琢良、草野徹、中嶋健太郎、平塚孝宏、赤木智徳、柴田智隆、上田貴威 當寺ヶ盛 学、白下英史、衛藤剛、猪股雅史、野口剛、白石憲男、北野正剛
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] New antioxidants, the vitamin E derivatives, improve anti-cancer drug-induced alopecia and inhibit various kinds of cancer growth (2013)
  • Author(s): Kentaro Nakajima, Masafumi Inomata,Yohei Kohno,Hidefumi shiroshita,Tsuyoshi Etoh, Norio Shiraishi,Satoshi Hagiwara,Tsuyoshi Noguchi and Seigo kitano
  • Organizer: 7th World Congress for Hair Research
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] The alpha-lipoic acid derivative, sodium zinc dihydrolipoylhistidinate(DHLHZn), reduces chemotherapy-induced alopecia in a rat model and inhibit various kinds of cancer growth (2013)
  • Author(s): Masafumi Inomata,Kentaro Nakajima,Yohei Kohno,Hidefumi Shiroshita,Tsuyoshi Etoh,Norio Shiraishi,Satoshi Hagiwara,Tsuyoshi Noguchi and Seigo Kitano
  • Organizer: 7th World Congress for Hair Research
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] 新規抗酸化剤は抗癌剤誘発脱毛を予防する！―頭皮の創傷治癒メカニズムに迫る― (2013)
  • Author(s): 杉田諭、中嶋健太郎、圓福真一朗、二日市琢良、草野徹、平塚孝宏、赤木智徳、柴田智隆、上田貴威、當寺ヶ盛学、白下英史、衛藤剛、猪股雅史、野口剛、白石憲男、野口隆之、北野正剛
  • Organizer: 第43回日本創傷治癒学会
  • Place of Presentation: 大分
• [Presentation] Dextran sulfate sodium (DSS)誘発性大腸炎モデルマウスに対する光線療法の有用性 (2013)
  • Author(s): 圓福真一朗、平塚孝宏、二日市琢良、中嶋健太郎、草野徹、杉田諭、赤木智徳、柴田智隆、上田貴威、當寺ヶ盛 学、白下英史、衛藤剛、猪股雅史、野口剛、白石憲男、野口隆之、北野正剛
  • Organizer: 第43回日本創傷治癒学会
  • Place of Presentation: 大分
• [Presentation] デキストラン硫酸ナトリウム大腸炎に対する光線照射の治療効果―炎症性腸疾患に対する光線を用いた新規治療法の開発― (2012)
  • Author(s): 平塚孝宏、井聖子、赤木智徳、當寺ヶ盛学、柴田智隆、白下英史、衛藤剛、猪股雅史、小山淑正、萩原聡、野口隆之、白石憲男、北野正剛
  • Organizer: 第3回癌・炎症とαリポ酸研究会
  • Place of Presentation: 大分県由布市
• [Presentation] 新規αリポ酸誘導体DHLHZｎのオキサプラチン誘導末梢神経障害に対する抑制効果；ラットモデルにおける検討 (2012)
  • Author(s): 杉田 諭、二日市琢良、草野徹、中嶋健太郎、平塚孝宏、赤木智徳、柴田智隆、上田貴威、當寺ヶ盛学、白下英史、衛藤剛、猪股雅史、野口剛、白石憲男、北野正剛
  • Organizer: 第42回日本創傷治癒学会
  • Place of Presentation: 北海道札幌市