The effectiveness of the newly antioxidant for radiation enteritis, dermatitis

Research Project

Project/Area Number	24791386
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General surgery
Research Institution	Oita University
Principal Investigator	SUGITA Satoshi 大分大学, 医学部, 客員研究員 (20625470)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	外科 / 放射線 / 実験外科学
Outline of Final Research Achievements	The therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation enterocolitis model was created by irradiation of rats with a single dose of 10 Gy. ETS-GS was administered subcutaneously (10 mg/kg/day) for five consecutive days from two days prior to irradiation. The ileal mucous membrane disorder of the ETS-GS administrated group was controlled in comparison with radiation exposure that received no ETS-GS group. In the ETS-GS administrated group, various inflammatory and oxidative stress markers were significantly lower than radiation exposure alone group. In this study, ETS-GS with antioxidant activity has a therapeutic effect on the symptoms of radiation enterocolitis in a rat model. Subsequently, the effectiveness of the ETS-GS for radiation dermatitis model is planned to study.