• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of autologous tissue small-caliber vascular grafts (biotubes)

Research Project

Project/Area Number 24791389
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKyoto Prefectural University of Medicine (2013-2014)
National Cardiovascular Center Research Institute (2012)

Principal Investigator

YAMANAMI Masashi  京都府立医科大学, 医学部附属病院, 専攻医 (30438204)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords小口径人工血管 / 組織工学 / 再生医療 / 生体内組織形成術 / バイオチューブ / 生体内組織形成技術 / 小口径代用血管
Outline of Final Research Achievements

We have developed autologous small-caliber vascular grafts, named "biotubes", by simple, safe and economical "in-body tissue architecture technology". In this study, we evaluated the long-term results of small-caliber biotubes.
Silicone rod molds were placed into subcutaneous pouches of rats, and after 1 month the implants were removed. Biotubes were obtained as tubular connective tissues. They were auto-implanted to the abdominal aorta. At over 1 year, graft status was evaluated by ultrasound echocardiography (UCG), magnetic resonance angiography (MRA) and histology. High patency rate of 89% (8/9) was obtained. UCG and MRA showed little stenosis, no aneurismal dilation. Histological evaluation revealed hierarchical vessel wall reconstruction including complete endothelialization, circumferentially oriented smooth muscle cells,elastin fibers mimicking native arteries.
The biotubes performed as excellent vascular grafts with high patency and regeneration activity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (24 results)

  • [Journal Article] Development of tissue-engineered self-expandable aortic stent grafts (Bio stent grafts) using in-body tissue architecture technology in beagles.2015

    • Author(s)
      Kawajiri H, Mizuno T, Moriwaki T, Ishibashi-Ueda H, Yamanami M, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater.

      Volume: 103(2) Issue: 2 Pages: 381-386

    • DOI

      10.1002/jbm.b.33218

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implantation study of a tissue-engineered self-expanding aortic stent graft (bio stent graft) in a beagle model.2015

    • Author(s)
      Kawajiri H, Mizuno T, Moriwaki T, Iwai R, Ishibashi-Ueda H, Yamanami M, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Artif Organs.

      Volume: 18(1) Issue: 1 Pages: 48-54

    • DOI

      10.1007/s10047-014-0796-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method2014

    • Author(s)
      Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Moriwaki T, Yamanami M, Oie T, Tatsumi E, Uechi M, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: Dec 9 Issue: 5 Pages: 1-10

    • DOI

      10.1002/jbm.b.33086

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014

    • Author(s)
      Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: (in press) Issue: 1 Pages: 1-10

    • DOI

      10.1002/jbm.b.33186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implantation study of small-caliber "biotube" vascular grafts in a rat model.2013

    • Author(s)
      Yamanami M
    • Journal Title

      J Artif Organs

      Volume: 99(2) Issue: 1 Pages: 59-65

    • DOI

      10.1007/s10047-012-0676-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 超小口径バイオチューブの長期移植評価.2014

    • Author(s)
      山南将志、岩井良輔、川尻英長、圓見純一郎、飯田秀博、神田圭一、夜久均、中山泰秀.
    • Organizer
      第52回日本人工臓器学会大会.
    • Place of Presentation
      札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体内で作製した結合組織膜(Biosheet)は修復材料としての自己心膜の代用になり得る.2014

    • Author(s)
      山南将志、水野壮司、渡辺太治、川尻英長、坂井修、神田圭一、夜久均、中山泰秀.
    • Organizer
      第67回日本胸部外科学会定期学術集会.
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-30 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long term auto implantation of autologous tissue small caliber vascular grafts (Biotubes).2014

    • Author(s)
      Yamanami M, Kawajiri H, Mizuno T, Iwai R, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Organizer
      XLI Annual ESAO Congress (European Society for Artificial Organs).
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long-term performance of autologous tissue ultra-small-caliber vascular grafts (biotubes) in a rat abdominal aorta replacement model.2014

    • Author(s)
      amanami M, Kawajiri H, Mizuno T, Iwai R, Enmi J, Iida H, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Organizer
      ESC Congress 2014. (European Society of Cardiology)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] バイオチューブ超小口径代用血管移植後の長期開存性評価.2014

    • Author(s)
      山南将志、水野壮司、神田圭一、夜久均、中山泰秀.
    • Organizer
      第42回日本血管外科学会学術総会.
    • Place of Presentation
      青森市
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long-term evaluation of autologous tissue small-caliber vascular grafts (biotubes) in a rat abdominal aorta replacement model.2014

    • Author(s)
      Yamanami M, Kawajiri H, Mizuno T, Iwai R, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Organizer
      63ed International Congress of the European Society for Cardiovascular and Endovascular Surgery (ESCVS).
    • Place of Presentation
      Nice, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long term patency and durability of in vivo tissue engineered autologous tube grafts "Biotubes".2013

    • Author(s)
      T Watanabe, K Kanda, M Yamanami, O Sakai, H Yaku, Y Nakayama.
    • Organizer
      62nd ESCVS (the European Society for Cardiovascular and Endovascular Surgery)
    • Place of Presentation
      レーゲンスブルグ ドイツ
    • Related Report
      2013 Research-status Report
  • [Presentation] Follow-up report on the biotube of 5-year implantation-angiographic and sonographic evaluations.2013

    • Author(s)
      T Watanabe, K Kanda, T Mizuno, Y Nakayama, H Yaku, M Yamanami.
    • Organizer
      XXXX ESAO (the European Society for Artificial Organs) Congress
    • Place of Presentation
      グラスゴー イギリス
    • Related Report
      2013 Research-status Report
  • [Presentation] 生体内組織形成技術を用いた小口径代用血管(バイオチューブ)移植後のコンプライアンス変化の検討2013

    • Author(s)
      山南将志、水野壮司、神田圭一、夜久均、中山泰秀
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Research-status Report
  • [Presentation] バイオチューブ人工血管移植後6年目の超音波による開存性、形態的変化の評価2013

    • Author(s)
      渡辺太治、山南将志、水野壮司、神田圭一、夜久均、中山泰秀
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Research-status Report
  • [Presentation] バイオチューブの無吻合移植:ステントカフとの一体成形2013

    • Author(s)
      川尻英長、山南将志、水野壮司、神田圭一、夜久均、中山泰秀
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Research-status Report
  • [Presentation] 大動脈ステントグラフト化バイオチューブ(バイオステントグラフト)の開発2013

    • Author(s)
      川尻英長、水野壮司、山南将志、神田圭一、夜久均、中山泰秀
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo tissue-engineered small diameter "biotube".2013

    • Author(s)
      K Kanda, T Watanabe, M Yamanami, O Sakai, H Yaku, Y Nakayama.
    • Organizer
      27th EACTS (the European Association for Cardio-Thoracic Surgery)
    • Place of Presentation
      ウィーン オーストリア
    • Related Report
      2013 Research-status Report
  • [Presentation] バイオチューブ小口径代用血管の開発2013

    • Author(s)
      山南将志、水野壮司、圓見純一郎、飯田秀博、神田圭一、夜久均、中山泰秀
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオシートの心房修復材への応用:移植3ヵ月後の変化2013

    • Author(s)
      山南将志、水野壮司、辻中貴大、神田圭一、夜久均、中山泰秀
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオチューブ小口径代用血管の開存性向上の工夫2013

    • Author(s)
      山南将志、水野壮司、圓見純一郎、飯田秀博、神田圭一、夜久均、中山泰秀
    • Organizer
      第41回日本血管外科学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Related Report
      2012 Research-status Report
  • [Presentation] By Rapid Arterialization, Completely Autologous Vascular Grafts without Synthetic Support Materials “BIOTUBEs” Showed no Degenerative Changes under Systemic Blood Pressure2012

    • Author(s)
      M. Yamanami, T. Watanabe, K. Kanda, H. Ishibashi-Ueda, H. Yaku, Y. Nakayama
    • Organizer
      The 61st ESCVS (the European Society for Cardiovascular and Endovascular Surgery)
    • Place of Presentation
      クロアチア ドブロブニク
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体内組織形成技術で作成した 心臓弁付Conduit (BIOVALVE)の 大動脈系自家移植実験2012

    • Author(s)
      山南将志、武輪能明、岸本祐一郎、荒川衛、住倉博仁、大沼健太郎、松井悠一、渡辺太治、神田圭一、夜久均、田地川勉、大場謙吉、妙中義之、巽英介、中山泰秀
    • Organizer
      第42回日本心臓血管外科学会学術集会
    • Place of Presentation
      秋田県秋田市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体内組織形成技術による循環器系再生医療デバイスの開発2012

    • Author(s)
      山南将志、渡辺太治、神田圭一、夜久均、上地正実、武輪能明、中山泰秀
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of Autologous Tissue Small Caliber Vascular Grafts (BIOTUBEs)2012

    • Author(s)
      M. Yamanami, T. Watanabe, K. Kanda, H. Ishibashi-Ueda, H. Yaku, Y. Nakayama
    • Organizer
      ESC (European Society of Cardiology) Congress 2012
    • Place of Presentation
      ドイツ ミュンヘン
    • Related Report
      2012 Research-status Report
  • [Presentation] BIOTUBE APPLICATION TO THE ARTERIOVENOUS SHUNT2012

    • Author(s)
      M. Yamanami, Y. Matsui, K. Kanda, Y. Nakayama
    • Organizer
      ESAO (European Society for Artificial Organs) XXXIX
    • Place of Presentation
      ドイツ ロストック
    • Related Report
      2012 Research-status Report
  • [Presentation] 自己体内で作製した結合組織膜(Bio-sheet)は 修復材料としての自己心膜の代用になり得るか?2012

    • Author(s)
      山南将志、水野壮司、辻中貴大、渡辺太治、坂井修、神田圭一、夜久均、中山泰秀
    • Organizer
      第65回日本胸部外科学会定期学術集会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオチューブの血液透析用 シャント用代用血管への応用の可能性2012

    • Author(s)
      山南将志、渡辺太治、坂井修、 神田圭一、夜久均、中山泰秀
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオシートの心房修復材への応用2012

    • Author(s)
      山南将志、水野壮司、辻中貴大、神田圭一、中山泰秀
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi