Mesenchymal Stem Cell transplantation for Reconstruction of Breast Cancer patients

• Project/Area Number: 24791392
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Keio University
• Principal Investigator: SEKI Tomoko 慶應義塾大学, 医学部, 助教 (70528900)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 幹細胞 / 乳房再建 / 細胞移植 / 組織工学 / 間葉系幹細胞 / 生体医工学

Outline of Final Research Achievements

This study was to investigate new strategy for the reconstruction of mammary gland after glandectomy for breast cancer patients using autologous mesenchymal stem cell transplantation with self absorbable hydrogel. The mouse model we used was an unique model generated by resecting mammary fat pad which is the immature breast tissue in mouse and mimicking the patients who suffered partial breast resection. The result of the transplantation of human mesenchymal stem cell demonstrated that the cells could sufficiently restore the space after the fat pad resection in mouse and showed no tumorigenesis or inflammatory response. Therefore, we assume that this new strategy using autologous mesenchymal stem cell for the reconstruction of the breast will be one of the options for breast cancer patient without surgical incision.

Research Products

• [Presentation] 原発性乳癌に対する乳頭温存乳房切除術の安全性の検証 (2014)
  • Author(s): 関朋子、松本暁子、村田健、高橋麻衣子、林田哲、神野浩光、岡林剛史、北川雄光
  • Organizer: 日本乳癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-11