Elucidation of liver regeneration mechanisms using novel NASH animal model
| Project/Area Number |
24791401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INAGAKI Natsuko 東京大学, 分子細胞生物学研究所, 特任研究員 (00611419)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝臓学 / NASH / 肝再生 / 肝臓 / 再生医学 |
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| Research Abstract |
Recently patients with non-alcoholic steatohepatitis (NASH) have been increased because of westernization of lifestyle in Japan, which evokes a serious problem in the society. The goal of the present study is to elucidate the difference in the regeneration mechanisms between NASH and normal livers using NASH animal models. Investigation for a long period observation of two NASH model mouse candidates proved that feeding of choline deficient amino acid diet to wild-type mice is appropriate to evoke NASH. Liver regeneration is significantly impaired in NASH liver compared with normal liver after 70% partial hepatectomy. Additionally the results by FACS analysis suggested the involvement of new blood cells in the delay of liver regeneration.
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Report
(3 results)
Research Products
(17 results)
