Research Project
Grant-in-Aid for Young Scientists (B)
Recently patients with non-alcoholic steatohepatitis (NASH) have been increased because of westernization of lifestyle in Japan, which evokes a serious problem in the society. The goal of the present study is to elucidate the difference in the regeneration mechanisms between NASH and normal livers using NASH animal models. Investigation for a long period observation of two NASH model mouse candidates proved that feeding of choline deficient amino acid diet to wild-type mice is appropriate to evoke NASH. Liver regeneration is significantly impaired in NASH liver compared with normal liver after 70% partial hepatectomy. Additionally the results by FACS analysis suggested the involvement of new blood cells in the delay of liver regeneration.
All 2014 2013 2012 2010
All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 4 results)
Biochem Biophys Res Commun
Volume: 430 Pages: 751-756
Biochem. Biophys. Res. Commun.
Volume: 430 Issue: 2 Pages: 751-756
10.1016/j.bbrc.2012.11.076
Prog Brain Res
Volume: 199 Pages: 129-141
In Progress in Brain Res
10.1016/b978-0-444-59427-3.00029-0
Retrovirology
Volume: 7 Pages: 90-90
