Analysis of the relationships between migration and differentiation of regulatory T cells and helper T-17 cells and cancer staging in the esophageal cancer.
| Project/Area Number |
24791404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 制御性T細胞 / 癌微小環境 / 過酸化水素 / 活性酸素 / アポトーシス / 癌免疫治療 / 食道癌 / Th17細胞 / ケモカイン / T-reg / Tｈ17細胞 |
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| Outline of Final Research Achievements |
An increase in regulatory T cells (Tregs) is observed in tumor microenvironments. Since it was suggested that Tregs showed a lower sensitivity toward oxidative stress in comparison with conventional T cells (Tcon), we investigated the H(2)O(2) production and apoptosis of Tregs in esophageal cancer tissues, employing flow cytometric analysis and immunohistochemical analysis. The increased tumor-infiltrating Tregs coexisted with elevated H(2)O(2) production according to disease progression. The grade of apoptosis in Tregs was less pronounced than that in Tcon, and there was a positive correlation between H(2)O(2) production and the grade of apoptosis in Tcon, while there was no correlation between H(2)O(2) production and the grade of apoptosis in Tregs. Moreover, Tregs were less sensitive to H(2)O(2)-induced apoptosis compared with Tcon in vitro. As conclusions, the increased prevalence of tumor-infiltrating Tregs closely related to their lower sensitivity to H(2)O(2)-induced apoptosis.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by ctla-4 blockade in a mouse model.2014
Author(s)
Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, Okonogi N, Maruyama T, Izawa S, Noda SE, Fujii H, Kono K, Nakano T.
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Journal Title
PLoS One.
Volume: 9(3)
Issue: 3
Pages: e92572-e92572
DOI
Related Report
Peer Reviewed / Open Access
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