Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Outline of Final Research Achievements |
A total of 169 IPMN and 108 pancreatic ductal adenocarcinoma (PDAC) patients were enrolled, and VEGF +405G/C and 460C/T SNPs were investigated. VEGF +405C/C was found more frequently in malignant IPMNs compared with +405G/G, and +405C allele was associated with malignant IPMNs compared with +405G. In branch duct IPMNs, VEGF +405C/C was significantly associated with malignant transformation, and there was a trend of VEGF +405C/C associated with malignant transformation of gastric type IPMNs. VEGF +405G/C SNP was significantly associated with malignant transformation in IPMNs, especially branch duct and gastric type IPMNs. VEGF +405G/C SNP might be helpful in predicting clinical course in pancreatic disease with potential for malignant transformation.
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