Discovery of novel predictive factor for pancreatic cancer and application for tailor-made treatment by use of single nucleotide polymorphism
Project/Area Number |
24791406
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Nagoya University |
Principal Investigator |
YAMADA Suguru 名古屋大学, 医学部附属病院, 病院講師 (30467287)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 一塩基多型 / 膵癌 / IPMN / VEGF |
Outline of Final Research Achievements |
A total of 169 IPMN and 108 pancreatic ductal adenocarcinoma (PDAC) patients were enrolled, and VEGF +405G/C and 460C/T SNPs were investigated. VEGF +405C/C was found more frequently in malignant IPMNs compared with +405G/G, and +405C allele was associated with malignant IPMNs compared with +405G. In branch duct IPMNs, VEGF +405C/C was significantly associated with malignant transformation, and there was a trend of VEGF +405C/C associated with malignant transformation of gastric type IPMNs. VEGF +405G/C SNP was significantly associated with malignant transformation in IPMNs, especially branch duct and gastric type IPMNs. VEGF +405G/C SNP might be helpful in predicting clinical course in pancreatic disease with potential for malignant transformation.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] A vascular endothelial growth factor gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm2015
Author(s)
Norimitsu Yabusaki, Suguru Yamada, Yoshie Shimoyama, Tsutomu Fujii, Mitsuro Kanda, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Akimasa Nakao, Yasuhiro Kodera
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Journal Title
Pancreas
Volume: 44
Issue: 4
Pages: 608-614
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm2014
Author(s)
Suguru Yamada, Tsutomu Fujii, Yoshie Shimoyama, Mitsuro Kanda,Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Akimasa Nakao, Yasuhiro Kodera
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Journal Title
Annals of surgical oncology
Volume: 21
Issue: 7
Pages: 2444-2452
DOI
Related Report
Peer Reviewed / Open Access
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