Discovery of novel predictive factor for pancreatic cancer and application for tailor-made treatment by use of single nucleotide polymorphism

• Project/Area Number: 24791406
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: YAMADA Suguru 名古屋大学, 医学部附属病院, 病院講師 (30467287)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 一塩基多型 / 膵癌 / IPMN / VEGF

Outline of Final Research Achievements

A total of 169 IPMN and 108 pancreatic ductal adenocarcinoma (PDAC) patients were enrolled, and VEGF +405G/C and 460C/T SNPs were investigated. VEGF +405C/C was found more frequently in malignant IPMNs compared with +405G/G, and +405C allele was associated with malignant IPMNs compared with +405G. In branch duct IPMNs, VEGF +405C/C was significantly associated with malignant transformation, and there was a trend of VEGF +405C/C associated with malignant transformation of gastric type IPMNs. VEGF +405G/C SNP was significantly associated with malignant transformation in IPMNs, especially branch duct and gastric type IPMNs. VEGF +405G/C SNP might be helpful in predicting clinical course in pancreatic disease with potential for malignant transformation.

Research Products

• [Journal Article] A vascular endothelial growth factor gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm (2015)
  • Author(s): Norimitsu Yabusaki, Suguru Yamada, Yoshie Shimoyama, Tsutomu Fujii, Mitsuro Kanda, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Akimasa Nakao, Yasuhiro Kodera
  • Journal Title: Pancreas Volume: 44 Issue: 4 Pages: 608-614
  • DOI: 10.1097/mpa.0000000000000305
  • Peer Reviewed / Open Access
• [Journal Article] Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm (2014)
  • Author(s): Suguru Yamada, Tsutomu Fujii, Yoshie Shimoyama, Mitsuro Kanda,Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Akimasa Nakao, Yasuhiro Kodera
  • Journal Title: Annals of surgical oncology Volume: 21 Issue: 7 Pages: 2444-2452
  • DOI: 10.1245/s10434-014-3565-1
  • Peer Reviewed / Open Access
• [Presentation] 血管内皮細胞増殖因子の一塩基多型による膵管内乳頭状粘液性腫瘍における悪性化予測 ＜優秀演題＞ (2014)
  • Author(s): 山田 豪，薮崎紀充，藤井 努，神田光郎，岩田直樹，小林大介，田中千恵，中山吾郎，杉本博行，小池聖彦，野本周嗣，藤原道隆，小寺泰弘
  • Organizer: JDDW 2014 (第12回消化器外科学会大会)
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市中央区)
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] A VEGF gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm (2014)
  • Author(s): Suguru Yamada, Norimitsu Yabusaki, Mitsuro Kanda, Goro Nakayama, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市西区）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 組織学的亜型と癌浸潤部亜型の観点から見たIPMN治療方針の検討 (2014)
  • Author(s): 山田 豪，藤井 努，神田光郎，小林大介，田中千恵，中山吾郎，杉本博行，小池聖彦，野本周嗣，藤原道隆，小寺泰弘
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田）
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] A vascular endothelial growth factor gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm (2014)
  • Author(s): Suguru Yamada, Norimitsu Yabusaki, Tsutomu Fujii, Mitsuro Kanda, Hiroyuki Sugimoto, Yasuhiro Kodera
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Philadelphia（USA）
  • Year and Date: 2014-04-18 – 2014-04-22