Research Project
Grant-in-Aid for Young Scientists (B)
To study the role of IFNalpha in the induction of apoptosis of HCC cells, we transduced interferon-alpha-receptor-2(IFNAR2)into the human HCC cell line. Cell cycle was visualized by induction of Fucci system. Time lapse imaging for 72 hours after IFNalpha or 5-FU treatment showed that IFNalpha induced cell death at G0/G1 phase whereas 5-FU induced cell death at S/G2/M phase. Time lapse imaging after synchronization of cell cycle revealed that cell death induced by IFNalpha was observed at G0/G1 phase following after S/G2/M phase. This showed S/G2/M phase was active point for IFNalpha.
All 2013 2012 Other
All Presentation (8 results)
