Iron controlled cancer therapy
| Project/Area Number |
24791424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 癌 / 血管新生 / 鉄 / 分子標的薬 |
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| Research Abstract |
Iron is an essential element for both normal and cancer cells in humans. Iron overload is known to induce some kinds of cancer, which suggests that prevention of iron overload may become a therapeutic strategy for cancer prevention. However, iron depletion mono-therapy by iron decreased treatment has not been thought to be superior to ordinary chemotherapy and is not part of the standard therapeutic strategy for the treatment of cancer. We revealed that iron depletion inhibited the cancer cell proliferation and reciprocally induced angiogenesis in vitro and in vivo. Treatment to deplete iron levels combined with anti-angiogenic therapy could induce a novel therapeutic effect in the treatment of cancer.
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Report
(3 results)
Research Products
(25 results)
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[Presentation] 鉄欠乏状態は肝細胞癌におけるソラフェニブの感受性を改善しうる2013
Author(s)
浦野真一, 大原利章, 勝部亮一, 渡邉伸一郎, 野間和広, 友野靖子, 田澤 大, 能祖一裕, 白川靖博, 貞森 裕, 藤原俊義
Organizer
第72回日本癌学会学術総会
Place of Presentation
東京
Year and Date
2013-10-24
Related Report
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[Presentation] 除鉄効果を利用した新たな消化器癌治療2013
Author(s)
大原利章, 白川靖博, 浦野真一, 前田直見, 勝部亮一, 渡辺伸一郎, 田辺俊介, 野間和広, 櫻間教文, 藤原俊儀
Organizer
第68回日本消化器外科学会総会
Place of Presentation
宮崎
Year and Date
2013-07-17
Related Report
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[Presentation] 血清鉄コントロールを用いた新たな肝細胞癌治療戦略2013
Author(s)
大原利章, 白川 靖博, 浦野 真一, 前田 直見, 渡邊 伸一郎, 田辺 俊介, 野間 和広, 能祖 一裕, 貞森 裕, 八木 孝仁 , 藤原 俊義
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Year and Date
2013-04-11
Related Report
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[Presentation] Iron depletion by deferasirox have a synergistic effect on sorafenib in hepatocellular carcinoma2013
Author(s)
Shinichi Urano, Toshiaki Ohara, Shinichiro Watanabe, Kazuhiro Noma, Yasuko Tomono, Hiroshi Tazawa, Masafumi Kataoka, Nouso Kazuhiro, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Organizer
104th Annual Meeting American Association for Cancer Research
Place of Presentation
Washington, USA
Year and Date
2013-04-10
Related Report
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[Presentation] 食道癌における除鉄による浸潤・転移能抑制の可能性2013
Author(s)
浦野真一, 大原利章, 渡辺伸一郎, 友野靖子, 木村文昭, 野間和広, 白川靖博, 藤原俊義
Organizer
文部科学省科学研究費補助金 がん研究分野の特性等を踏まえた支援活動 平成24年度「個体レベルでのがん研究支援活動」ワークショップ
Place of Presentation
滋賀
Year and Date
2013-02-07
Related Report
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[Presentation] 食道癌における除鉄による遊走, 浸潤能抑制作用の検討2012
Author(s)
浦野真一, 大原利章, 前田直見, 渡辺伸一郎, 田辺俊介, 野間和広, 友野靖子, 白川靖博, 木村文昭, 藤原俊義
Organizer
第36回日本鉄バイオサイエンス学会学術集会
Place of Presentation
札幌
Year and Date
2012-09-02
Related Report
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