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New development of pancreatic cancer stromal control based on the molecular analysis

Research Project

Project/Area Number 24791430
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

FUJITA Hayato  九州大学, 医学(系)研究科(研究院), 共同研究員 (40611281)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵癌 / 間葉系幹細胞 / 線維増生
Research Abstract

CD90-positive fibroblasts were observed in 93% or more in the analysis of pancreatic stellate cells and this CD90 could be the key surface marker to regulate desmoplasia. In the analysis of pancreatic cancer cells, CD105-positive pancreatic cancer cells showed the specific gene expression of epithelial-mesenchymal transition and these mobility were enhanced by pancreatic stellate cells. In the case of CD166, CD166-negative pancreatic cancer cells showed strong mobility and invasiveness compared with CD166-positive cells. Furthermore, the anti-fibrotic drug "Pirfenidone" inhibited pancreatic cancer desmoplasia mainly contributed by pancreatic stellate cells and it had been suggested that regulation of stroma could suppress progression for pancreatic cancer.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (13 results)

  • [Journal Article] Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells.2013

    • Author(s)
      Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Naoki Ikenaga, Kenji Fujiwara, Ming Zhao, Lin Cui, Koji Shindo, Kazuhiro Mizumoto, and Masao Tanaka
    • Journal Title

      Cancer Research

      Volume: 73 Issue: 7 Pages: 2345-2356

    • DOI

      10.1158/0008-5472.can-12-3180

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Migrato ry Activity of CD105+ Pancreatic Cancer2013

    • Author(s)
      Fujiwara K, Ohuchida K, Ohtsuka T, M izumoto K, Shindo K, Ikenaga N, Cui L, Takahata S, Aishima S, Tanaka M
    • Journal Title

      Cells Is Strongly Enhanced by Pancreat ic Stellate Cells Pancreas

      Volume: 42(8) Pages: 1283-90

    • Related Report
      2013 Final Research Report
  • [Journal Article] Migratory Activity of CD105+ Pancreatic Cancer Cells Is Strongly Enhanced by Pancreatic Stellate Cells2013

    • Author(s)
      Fujiwara K et al
    • Journal Title

      Pancreas

      Volume: 42 Pages: 1283-90

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD271^+ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells2012

    • Author(s)
      Kenji Fujiwara
    • Journal Title

      PLoS One

      Volume: 12 Issue: 12 Pages: e52682-e52682

    • DOI

      10.1371/journal.pone.0052682

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical Significance of Stromal CD90 and alpha-SMA Expression in Pancreatic Cancer American Pancreatic Association2013

    • Author(s)
      Sada M, et al
    • Organizer
      44th Annual Meeting
    • Place of Presentation
      Miami
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] A CD166 negative subpopulation of pancreatic cancer cells has strong invasive and migratory activity2013

    • Author(s)
      Fujiwara K, et al
    • Organizer
      DDW2013
    • Place of Presentation
      Orlando
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells 2012 Joint Meeting of American Pancreatic2012

    • Author(s)
      Fujiwara K, et al
    • Organizer
      Association and International Association of Pancreatology
    • Place of Presentation
      Miami
    • Year and Date
      2012-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] CD166陰性膵癌細胞は強い浸潤能・遊走能を有する

    • Author(s)
      藤原謙次
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] The investigation of CD146 in pancreatic cancer associated fibroblast

    • Author(s)
      趙茗
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膵癌間質におけるCD90とα-SMA発現の意義

    • Author(s)
      佐田政史
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A CD166 negative subpopulation of pancreatic cancer cells has strong invasive and migratory activity

    • Author(s)
      Fujiwara K et al.
    • Organizer
      DDW2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD166 Expression Characterized Tumorigenicity, and Invasive and Migratory Activities of Pancreatic Cancer Cell Lines

    • Author(s)
      Fujiwara K et al.
    • Organizer
      American Pancreatic Association, 44th Annual Meeting
    • Place of Presentation
      Miami
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical Significance of Stromal CD90 and alpha-SMA Expression in Pancreatic Cancer

    • Author(s)
      Sada M et al.
    • Organizer
      American Pancreatic Association, 44th Annual Meeting
    • Place of Presentation
      Miami
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膵癌におけるCD271陽性膵星細胞の意義

    • Author(s)
      藤原 謙次
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] CD105陽性膵癌細胞は膵星細胞から影響を受けて強い遊走能を獲得する

    • Author(s)
      藤原 謙次
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Related Report
      2012 Research-status Report
  • [Presentation] CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction with cancer cells

    • Author(s)
      Kenji Fujiwara
    • Organizer
      International Symposium on Pancreas Cancer 2012 in Kyoto
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells

    • Author(s)
      Kenji Fujiwara
    • Organizer
      012 Joint Meeting of APA and IAP
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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