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Elucidation of the radioresistance mechanism on the microenviroment of pancreatic cancer and control of the stroma cells causing radioresistance by newly artificial virus.

Research Project

Project/Area Number 24791431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

ONIMARU Manabu  九州大学, 医学(系)研究科(研究院), 共同研究員 (80529876)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膵癌 / HDAC1 / DNA / Double Strand Break / Trichostatin A / iRNA / 放射線抵抗性 / NG2 / PDGFRβ / 低酸素環境 / CTGF
Research Abstract

Pancreatic ductal adenocarcinoma (PDA) is characterised by aggressive tumor spread, early metastasis and a poor prognosis. Standard therapy for PDA patients includes not only surgery and chemotherapy but also radiotherapy. However, there have been few detailed molecular biological studies to investigate about the effect of radiotherapy on PDA. It was reported that histone deacetylase 1 (HDAC1) is responsible for DNA repair of double strand breaks after irradiation in human fibroblasts. Here, we examined HDAC1 is involved in the mechanism of radioresistance of PDA. The irradiated pancreatic cancer cell lines reduced the radiosensitivity and increased the HDAC1 mRNA expression. The radioresistance was decreased after the addition of low-concentration TSA or knockdown of HDAC1 in pancreatic cancer cell lines. The present data suggested that HDAC1 is invoved in the mechanism of the radioresistance of pancreatic cancer cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer.2014

    • Author(s)
      Akagawa S, Ohuchida K, Torata N, Hattori M, Eguchi D, Fujiwara K, Kozono S, Cui L, Ikenaga N, Ohtsuka T, Oishima S, Mizumoto K, Oda Y, Tanaka M
    • Journal Title

      Int J Oncol

      Volume: 45 Issue: 1 Pages: 113-120

    • DOI

      10.3892/ijo.2014.2391

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.2012

    • Author(s)
      Eguchi D
    • Journal Title

      Journal of Surgical Research

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD271^+ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells2012

    • Author(s)
      Kenji Fujiwara
    • Journal Title

      PLoS One

      Volume: 12 Issue: 12 Pages: e52682-e52682

    • DOI

      10.1371/journal.pone.0052682

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 膵癌細胞株におけるHiston deacetylase 1の放射線耐性に関する評価2013

    • Author(s)
      田中友晴, 小薗真吾, 大内田研宙, 水元一博, 田中雅夫
    • Organizer
      日本外科学会総会
    • Place of Presentation
      九州大学 臨床・腫瘍外科
    • Related Report
      2013 Final Research Report
  • [Presentation] Histon deacetylase 1 is responsible for radioresistance of pancreatic cancer cells2013

    • Author(s)
      Tomoharu Tanaka, Shingo Kozono, Kenoki Ohuchida, Kazuhiro Mizumoto and Masao Tanaka
    • Organizer
      American Pancreatic Association
    • Place of Presentation
      Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
    • Related Report
      2013 Final Research Report
  • [Presentation] Histon deacetylase 1 is responsible for radioresistance of pancreatic cancer cells.

    • Author(s)
      Tanaka T et al
    • Organizer
      American Pancreatic Association, 44th Annual Meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pancreatic cancer cells in hypoxia enhance the motility of pancreatic stellate cells via increased secretion of vascular endothelial growth factor

    • Author(s)
      Eguchi D
    • Organizer
      2012 Joint Meeting of APA and IAP
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵星細胞は低酸素下でCTGFの分泌を介して膵癌の浸潤に寄与する

    • Author(s)
      江口 大樹
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵癌におけるCD271陽性膵星細胞の意義

    • Author(s)
      藤原 謙次
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction with cancer cells

    • Author(s)
      Fujiwara K
    • Organizer
      International Symposium on Pancreas Cancer 2012 in Kyoto
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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