Novel development in viral therapy targeting pancreatic cancer microenvironment – viral spread and transduction efficiency in pancreatic stroma
| Project/Area Number |
24791432
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
YASUI Takaharu 九州大学, 医学(系)研究科(研究院), 共同研究員 (60611283)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | hypoxia / stellate cells / 膵癌微小環境 / 膵星細胞 / 抗線維化薬 / 低酸素微小管環境 / 癌間質相互作用 / CTGF |
|---|
| Research Abstract |
The achievements in the present study are as follows. (1) Pancreatic stellate cells cultured in hypoxic condition promote invasive ability of pancreatic cancer cells. (2) The invasive ability of pancreatic cancer cells in hypoxic condition is promoted by connective tissue growth factor (CTGF) secreted by pancreatic stellate cells. (3) Lower expression of CD90 is associated with good prognosis in surgically resected pancreatic cancer patients. (4) The migratory and invasive ability of pancreatic cancer cells are increased when co-cultured with CD146 knockdown pancreatic stellate cells.
|
Report
(3 results)
Research Products
(12 results)
