| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We performed 70% hepatectomy in mice receiving normal saline, LSKL peptide, and sham operation.LSKL peptide was administered intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by ELISA system in patients with hepatectomy. LSKL peptide administration attenuated Smad2 phosphorylation at 6h. S-phase entry of hepatocytes was accelerated at 24 and 48h by LSKL peptide administration, and which resulted in faster recovery of the residual liver and body weight. H&E staining and blood biochemical examinations revealed no significant adverse effects occurred following the two LSKL peptide administrations. LSKL peptide during the early period after hepatectomy can promote liver regeneration. The transient inhibition of TSP-1/TGF-beta signal activation using LSKL peptide in the early period after hepatectomy may thus be a promising strategy to promote liver regeneration following hepatectomy.
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