| Project/Area Number |
24791437
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
MEGURO Makoto 札幌医科大学, 医学部, 講師 (50448601)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | FloTrac/Vigileo / LIver resection / prediction / liver failure / monitoring / ScvO2 / stroke volume variation / ビジリオモニタリング / 肝切除 / 肝切除後肝不全予測 / 肝切除術後肝不全予測 / フロートラックビジリオシステム / 術中リアルタイムモニタリング / 上大静脈内酸素飽和度（ScvO2) / SVV / 術後肝機能障害予測 / 輸血 / 出血 / 循環不全 |
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| Outline of Final Research Achievements |
We examined whether the data obtained by monitoring central venous oxygen saturation (ScvO2) and/or stroke volume variation (SVV) during hepatectomy, as measured with the FloTrac/Vigileo system, can predict postoperative liver dysfunction. The cutoff values for ΔScvO2 and mean SVV for predicting the highest postoperative T. Bil level to be 3.0 mg/dL or more with the highest sensitivity and specificity were found to be 10.2% and 13.6%, respectively.
Our results suggest that ΔScvO2 and mean SVV can predict postoperative liver dysfunction. When ΔScvO2 and mean SVV exceed 10.2% and 13.6%, respectively, we advocate that adequate attention be paid to postoperative liver dysfunction, and that early intraoperative general circulatory management measures be implemented as needed.
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